MINAMESTANE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H23NO2
Molecular Weight	297.3914
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12CC[C@H]3[C@@H](C=CC4=C(N)C(=O)C=C[C@]34C)[C@@H]1CCC2=O

InChI

InChIKey=DAKHYLIFCYPHQW-KZQROQTASA-N

InChI=1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8422695 | https://adisinsight.springer.com/drugs/800002545

Farmitalia-Carlo Erba developed minamestane (code name FCE-24928) as a steroidal aromatase inhibitor for the treatment of cancer. This drug was in phase I clinical trial in Italy, but development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma.	1994-02-04	8148992
Antitumor activity of the aromatase inhibitor FCE 24928 on DMBA-induced mammary tumors in ovariectomized rats treated with testosterone.	1993	8422695
High-performance liquid chromatographic analysis of FCE 24304 (6-methylenandrosta-1,4-diene-3,17-dione) and FCE 24928 (4-aminoandrosta-1,4,6-triene-3,17-dione), two new aromatase inhibitors.	1992-02-28	1639908

Name

Type

Language

minamestane [INN]

Preferred Name

English

MINAMESTANE

Official Name

English

4-AMINOANDROSTA-1,4,6-TRIENE-3,17-DIONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2017