Details
Stereochemistry | ACHIRAL |
Molecular Formula | C43H47N2O6S2.Na |
Molecular Weight | 774.963 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 4 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC1(C)C(=CC=CC=CC=CC2=[N+](CCCCS([O-])(=O)=O)C3=CC=C4C=CC=CC4=C3C2(C)C)N(CCCCS([O-])(=O)=O)C5=CC=C6C=CC=CC6=C15
InChI
InChIKey=MOFVSTNWEDAEEK-UHFFFAOYSA-M
InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
DescriptionSources: https://www.drugs.com/pro/indocyanine-green.html
Sources: https://www.drugs.com/pro/indocyanine-green.html
ICG is a cyanine fluorescent dye which is used in medicine as an indicator substance (for photometric hepatic function diagnostics and fluorescence angiography) in cardiac, circulatory, hepatic and ophthalmic conditions. It is administered intravenously and, depending on liver performance, is eliminated from the body with a half life of approx. 3-4 minutes.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21964696
Curator's Comment: Known to be CNS non-penetrant in mice and rabbits, where it was used to monitor BBB disruptions. Human data not available.
Originator
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | IC-GREEN INJECTABLE Approved UseIndocyanine Green is indicated for ophthalmic angiography. In ophtalmic angiography, Indocyanine Green is used for diagnosis of age-related macular degeneration, choroidal neovascularization, polypoidal choroidal vasculopathy, retinal angiomatous proliferation, choroidal melanoma, retinal damage and other pathological conditions Launch Date1959 |
|||
Diagnostic | IC-GREEN INJECTABLE Approved UseIndocyanine Green is indicated for determining cardiac and heptic output during various types of surgeries. Launch Date1959 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
68095.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26629038 |
15 mg/kg single, intravenous dose: 15 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
INDOCYANINE GREEN ACID FORM plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
121.6 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10883415 |
0.5 mg/kg single, intravenous dose: 0.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: TRIAZOLAM |
INDOCYANINE GREEN ACID FORM plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
85 mg × min/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8822042 |
0.5 mg/kg single, intravenous dose: 0.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
INDOCYANINE GREEN ACID FORM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
503070.1 ng × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26629038 |
15 mg/kg single, intravenous dose: 15 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
INDOCYANINE GREEN ACID FORM plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
2.06 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10883415 |
0.5 mg/kg single, intravenous dose: 0.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: TRIAZOLAM |
INDOCYANINE GREEN ACID FORM plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
3.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8822042 |
0.5 mg/kg single, intravenous dose: 0.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
INDOCYANINE GREEN ACID FORM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
79.5 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26629038 |
15 mg/kg single, intravenous dose: 15 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
INDOCYANINE GREEN ACID FORM plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
5% |
INDOCYANINE GREEN ACID FORM serum | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
5 mg single, intravenous |
unhealthy, 46 n = 1 Health Status: unhealthy Age Group: 46 Sex: M Population Size: 1 Sources: |
Other AEs: Anaphylactoid reaction... |
27 mg single, intravenous Dose: 27 mg Route: intravenous Route: single Dose: 27 mg Sources: |
unhealthy, 48 n = 1 Health Status: unhealthy Age Group: 48 Sex: M Population Size: 1 Sources: |
Other AEs: Anaphylactoid reaction... |
5 mg single, intravenous Dose: 5 mg Route: intravenous Route: single Dose: 5 mg Sources: |
unhealthy, 63 n = 1 Health Status: unhealthy Condition: heart failure Age Group: 63 Sex: M Population Size: 1 Sources: |
Other AEs: Anaphylactoid reaction... |
5 mg single, intravenous |
unhealthy, 66 n = 1 Health Status: unhealthy Age Group: 66 Sex: M Population Size: 1 Sources: |
Other AEs: Anaphylactoid reaction... |
0.5 mg/kg single, intravenous Dose: 0.5 mg/kg Route: intravenous Route: single Dose: 0.5 mg/kg Sources: |
unhealthy, 70 n = 1 Health Status: unhealthy Age Group: 70 Sex: F Population Size: 1 Sources: |
Other AEs: Anaphylactoid reaction... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Anaphylactoid reaction | 5 mg single, intravenous |
unhealthy, 46 n = 1 Health Status: unhealthy Age Group: 46 Sex: M Population Size: 1 Sources: |
|
Anaphylactoid reaction | 27 mg single, intravenous Dose: 27 mg Route: intravenous Route: single Dose: 27 mg Sources: |
unhealthy, 48 n = 1 Health Status: unhealthy Age Group: 48 Sex: M Population Size: 1 Sources: |
|
Anaphylactoid reaction | 5 mg single, intravenous Dose: 5 mg Route: intravenous Route: single Dose: 5 mg Sources: |
unhealthy, 63 n = 1 Health Status: unhealthy Condition: heart failure Age Group: 63 Sex: M Population Size: 1 Sources: |
|
Anaphylactoid reaction | 5 mg single, intravenous |
unhealthy, 66 n = 1 Health Status: unhealthy Age Group: 66 Sex: M Population Size: 1 Sources: |
|
Anaphylactoid reaction | 0.5 mg/kg single, intravenous Dose: 0.5 mg/kg Route: intravenous Route: single Dose: 0.5 mg/kg Sources: |
unhealthy, 70 n = 1 Health Status: unhealthy Age Group: 70 Sex: F Population Size: 1 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Page: 9627.0 |
yes [Ki 0.112 uM] | |||
Page: 176.0 |
yes | |||
Page: 13677.0 |
yes | |||
Page: 176.0 |
yes | |||
Page: 176.0 |
yes | |||
Page: 176.0 |
yes |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubs.acs.org/doi/abs/10.1021/mp300472y Page: 3599.0 |
no | |||
Sources: https://pubs.acs.org/doi/abs/10.1021/mp300472y Page: 3599.0 |
yes | |||
Page: 176.0 |
yes | |||
Page: 176.0 |
yes | |||
Sources: https://pubs.acs.org/doi/abs/10.1021/mp300472y Page: 3599.0 |
yes |
PubMed
Title | Date | PubMed |
---|---|---|
Survey of complications of indocyanine green angiography in Japan. | 1994 Dec 15 |
|
Hypotensive shock as a complication of infracyanine green injection. | 1998 |
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Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. | 2002 Jul |
|
Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. | 2006 Jan 25 |
|
Retinal pigmented epithelial cells cytotoxicity and apoptosis through activation of the mitochondrial intrinsic pathway: role of indocyanine green, brilliant blue and implications for chromovitrectomy. | 2013 |
|
Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 Dec |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/pro/indocyanine-green.html
The usual doses of Indocyanine Green for Injection USP for dilution curves are as follows: adults - 5.0 mg, children - 2.5 mg, infants - 1.25 mg. These doses of the dye are usually injected in 1 mL volume. An average of five dilution curves are recommended in the performance of a diagnostic cardiac catheterization. The total dose of dye injected should be kept below 2 mg/kg.
Route of Administration:
Intravenous
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C461
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NDF-RT |
N0000175533
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NCI_THESAURUS |
C390
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WHO-ATC |
V04CX01
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NDF-RT |
N0000175536
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CHEMBL1615807
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31696
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5775
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INDOCYANINE GREEN
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C65913
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222-751-5
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19190
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m6272
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1340009
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3599-32-4
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3413
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SUB14208MIG
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3300
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ACTIVE MOIETY
SUBSTANCE RECORD