U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H15NO4
Molecular Weight 273.2839
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZELANDOPAM

SMILES

OC1=CC=C(C=C1O)[C@@H]2CNCC3=C2C=CC(O)=C3O

InChI

InChIKey=FULLEMQICAKPOE-JTQLQIEISA-N
InChI=1S/C15H15NO4/c17-12-3-1-8(5-14(12)19)10-6-16-7-11-9(10)2-4-13(18)15(11)20/h1-5,10,16-20H,6-7H2/t10-/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/9809482 | https://www.pharmacodia.com/yaodu/html/v1/chemicals/9885db9d9ee078055567f91ba45eabde.html | http://adisinsight.springer.com/drugs/800002584

YM-435 is a dopamine D1 agonist. The renal and cardiovascular effects of YM-435 may be suitable for the treatment of patients with renal insufficiency, heart failure and hypertension. It has been in phase II clinical trials for the treatment of heart failure and hypertension. YM435 may be useful in the preservation of renal function in ischemia-induced acute renal failure. Also, it might be a useful as therapeutic agent for the treatment of congestive heart failure.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: 489110.0
Gene Symbol: DRD1
2.9 nM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
Effect of zelandopam, a dopamine D1-like receptor agonist, in puromycin aminonucleoside nephrosis rats.
2005 Mar 7
Patents

Sample Use Guides

Dog: 0.1-3 ug/kg/min
Route of Administration: Intravenous
In Vitro Use Guide
YM-435 displayed a capacity to promote cAMP formation in bovine retina when ATP/GppNHp was present. The maximally stimulated level of CAMP induced by YM 435 (210% of the controls; ATP/GppNHp only, no agonist added), was attained with 10 uM agonist. The EC50 value of YM-435-induced cAMP formation was 1.97 uM.
Name Type Language
ZELANDOPAM
INN   WHO-DD  
INN  
Official Name English
zelandopam [INN]
Common Name English
Zelandopam [WHO-DD]
Common Name English
(-)-(S)-4-(3,4-DIHYDROXYPHENYL)-1,2,3,4-TETRAHYDRO-7,8-ISOQUINOLINEDIOL
Systematic Name English
SELANDOPAM
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66884
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2105532
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
PRIMARY
FDA UNII
IR6XYD8SAX
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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SMS_ID
300000036959
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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EPA CompTox
DTXSID2048820
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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MESH
C073504
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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NCI_THESAURUS
C66688
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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PUBCHEM
3078105
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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CAS
139233-53-7
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
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INN
7948
Created by admin on Fri Dec 15 16:30:42 GMT 2023 , Edited by admin on Fri Dec 15 16:30:42 GMT 2023
PRIMARY