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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8NO3.Na
Molecular Weight 201.1545
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACEDOBEN SODIUM

SMILES

[Na+].CC(=O)NC1=CC=C(C=C1)C([O-])=O

InChI

InChIKey=QCTHGBUDZUJILN-UHFFFAOYSA-M
InChI=1S/C9H9NO3.Na/c1-6(11)10-8-4-2-7(3-5-8)9(12)13;/h2-5H,1H3,(H,10,11)(H,12,13);/q;+1/p-1

HIDE SMILES / InChI

Description

Acedoben (4-acetamidobenzoic acid) is a benzoic acid derivative and a metabolite of benzocaine. It is a component of immunomodulatory drug inosine pranobex, which is used to treat mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
IMUNOVIR
Primary
IMUNOVIR
Primary
IMUNOVIR
PubMed

PubMed

TitleDatePubMed
Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection.
1993 Jun
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.
1997 Dec 5
Individual differences in Scanpaths correspond with serotonin transporter genotype and behavioral phenotype in rhesus monkeys (Macaca mulatta).
2009
The human brain in numbers: a linearly scaled-up primate brain.
2009
Rhesus monkeys' valuation of vocalizations during a free-choice task.
2009 Nov 18
Ambiguity aversion in rhesus macaques.
2010
Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions.
2010
Following gaze: gaze-following behavior as a window into social cognition.
2010
Coordinated scaling of cortical and cerebellar numbers of neurons.
2010
Regioselective carboxylation of catechol by 3,4-dihydroxybenzoate decarboxylase of Enterobacter cloacae P.
2010 May
Patents

Sample Use Guides

In Vivo Use Guide
Mucocutaneous herpes simplex: 1 g q.d.s. (4g daily), for 7 -14 days. Genital warts: 1g t.d.s. (3g daily), for 14-28 days as adjunctive therapy to podophyllin or carbon dioxide laser. Subacute sclerosing panencephalitis (SSPE): 50-100mg/kg daily, in divided does every 4 hours.
Route of Administration: Oral
In Vitro Use Guide
Inosine pranobex has been shown to stimulate various indices of metabolic activity of macrophages and monocytes. In vitro exposure to inosine pranobex or to 24-hour supernatants obtained from mononuclear cells pretreated with the drug restored chemotaxis to normal or near normal levels. Incubation with inosine pranobex in vitro stimulated the production of interleukin-l (lymphocyte activating factor) in human monocytes.
Name Type Language
ACEDOBEN SODIUM
WHO-DD  
Common Name English
SODIUM 4-ACETAMIDOBENZOATE
Systematic Name English
BENZOIC ACID, 4-(ACETYLAMINO)-, SODIUM SALT (1:1)
Common Name English
SODIUM P-ACETAMIDOBENZOATE
Common Name English
ACEDOBEN SODIUM [WHO-DD]
Common Name English
BENZOIC ACID, 4-(ACETYLAMINO)-, SODIUM SALT
Common Name English
SODIUM P-ACETYLAMINOBENZOATE
Common Name English
Code System Code Type Description
EPA CompTox
29305-16-6
Created by admin on Tue Mar 06 11:30:36 UTC 2018 , Edited by admin on Tue Mar 06 11:30:36 UTC 2018
PRIMARY
CAS
29305-16-6
Created by admin on Tue Mar 06 11:30:36 UTC 2018 , Edited by admin on Tue Mar 06 11:30:36 UTC 2018
PRIMARY