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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8NO3.Na
Molecular Weight 201.1545
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACEDOBEN SODIUM

SMILES

[Na+].CC(=O)NC1=CC=C(C=C1)C([O-])=O

InChI

InChIKey=QCTHGBUDZUJILN-UHFFFAOYSA-M
InChI=1S/C9H9NO3.Na/c1-6(11)10-8-4-2-7(3-5-8)9(12)13;/h2-5H,1H3,(H,10,11)(H,12,13);/q;+1/p-1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2431857

Acedoben (4-acetamidobenzoic acid) is a benzoic acid derivative and a metabolite of benzocaine. It is a component of immunomodulatory drug inosine pranobex, which is used to treat mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
IMUNOVIR

Approved Use

Imunovir tablets are indicated in the management of mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.

Launch Date

4.37615985E11
Primary
IMUNOVIR

Approved Use

Imunovir tablets are indicated in the management of mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.

Launch Date

4.37615985E11
Primary
IMUNOVIR

Approved Use

Imunovir tablets are indicated in the management of mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.

Launch Date

4.37615985E11
PubMed

PubMed

TitleDatePubMed
Metabolites of a blocked chloramphenicol producer.
2003 Jan
PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS).
2004 Jan-Feb
Individual differences in Scanpaths correspond with serotonin transporter genotype and behavioral phenotype in rhesus monkeys (Macaca mulatta).
2009
General intelligence in another primate: individual differences across cognitive task performance in a New World monkey (Saguinus oedipus).
2009 Jun 17
Rhesus monkeys' valuation of vocalizations during a free-choice task.
2009 Nov 18
Following gaze: gaze-following behavior as a window into social cognition.
2010
Regioselective carboxylation of catechol by 3,4-dihydroxybenzoate decarboxylase of Enterobacter cloacae P.
2010 May
Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes.
2015 Jun
Patents

Sample Use Guides

Mucocutaneous herpes simplex: 1 g q.d.s. (4g daily), for 7 -14 days. Genital warts: 1g t.d.s. (3g daily), for 14-28 days as adjunctive therapy to podophyllin or carbon dioxide laser. Subacute sclerosing panencephalitis (SSPE): 50-100mg/kg daily, in divided does every 4 hours.
Route of Administration: Oral
In Vitro Use Guide
Inosine pranobex has been shown to stimulate various indices of metabolic activity of macrophages and monocytes. In vitro exposure to inosine pranobex or to 24-hour supernatants obtained from mononuclear cells pretreated with the drug restored chemotaxis to normal or near normal levels. Incubation with inosine pranobex in vitro stimulated the production of interleukin-l (lymphocyte activating factor) in human monocytes.
Name Type Language
ACEDOBEN SODIUM
WHO-DD  
Common Name English
SODIUM 4-ACETAMIDOBENZOATE
Systematic Name English
BENZOIC ACID, 4-(ACETYLAMINO)-, SODIUM SALT (1:1)
Common Name English
SODIUM P-ACETAMIDOBENZOATE
Common Name English
Acedoben Sodium [WHO-DD]
Common Name English
BENZOIC ACID, 4-(ACETYLAMINO)-, SODIUM SALT
Common Name English
SODIUM P-ACETYLAMINOBENZOATE
Common Name English
Code System Code Type Description
DRUG BANK
DBSALT002366
Created by admin on Fri Dec 15 15:46:36 UTC 2023 , Edited by admin on Fri Dec 15 15:46:36 UTC 2023
PRIMARY
PUBCHEM
23681162
Created by admin on Fri Dec 15 15:46:36 UTC 2023 , Edited by admin on Fri Dec 15 15:46:36 UTC 2023
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EPA CompTox
DTXSID10183550
Created by admin on Fri Dec 15 15:46:36 UTC 2023 , Edited by admin on Fri Dec 15 15:46:36 UTC 2023
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FDA UNII
IO8823D6X7
Created by admin on Fri Dec 15 15:46:36 UTC 2023 , Edited by admin on Fri Dec 15 15:46:36 UTC 2023
PRIMARY
CAS
29305-16-6
Created by admin on Fri Dec 15 15:46:36 UTC 2023 , Edited by admin on Fri Dec 15 15:46:36 UTC 2023
PRIMARY