Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H34F2O5 |
Molecular Weight | 404.4885 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC(=O)[C@H](CCCCCCC(O)=O)[C@@]1([H])CC[C@@](O)(O2)C(F)(F)C[C@@H](C)CC
InChI
InChIKey=SDDSJMXGJNWMJY-BRHAQHMBSA-N
InChI=1S/C21H34F2O5/c1-3-14(2)13-20(22,23)21(27)11-10-16-15(17(24)12-18(16)28-21)8-6-4-5-7-9-19(25)26/h14-16,18,27H,3-13H2,1-2H3,(H,25,26)/t14-,15+,16+,18+,21+/m0/s1
Cobristone is a locally acting chloride channel activator that works to stimulate and protect the mucosal barrier function. Cobristone is being developed by the Sucampo Pharmaceuticals, Inc. for the prevention of oral mucositis and for the treatment of non-erosive reflux disease (NERD), a major subtype of gastroesophageal reflux disease. The development of the drug was terminated after phase 2 clinical trials failed to meet its primary endpoints.
Approval Year
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
158302
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NCI_THESAURUS |
C78276
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admin on Fri Dec 15 15:42:40 GMT 2023 , Edited by admin on Fri Dec 15 15:42:40 GMT 2023
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SS-121
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IL870Q3Z8I
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8865
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16757521
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100000178230
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333963-42-1
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C78117
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DB05514
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CHEMBL2103799
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DTXSID80187025
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ACTIVE MOIETY