Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C26H28N6O.ClH |
| Molecular Weight | 477.001 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)N1CCN(CC2=CN=C(O2)C3=CC(=CC4=C3C=NN4)C5=CC=CC6=C5C=CN6)CC1
InChI
InChIKey=GECUEJGEJLAXQA-UHFFFAOYSA-N
InChI=1S/C26H28N6O.ClH/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24;/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30);1H
GSK-2269557 (nemiralisib), a PI3Kδ inhibitor, is in development as an anti-inflammatory drug for the treatment of inflammatory airways disease. Studies in moderate or severe stable COPD patients have shown an acceptable safety and tolerability profile when GSK-2269557 was administered via inhalation. Cough was the most commonly reported adverse event.
Approval Year
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Code | English |
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1254036-77-5
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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GSK-2269557
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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PRIMARY | MedKoo CAT NO: 522375CAS NO: 1254036-77-5(HCl salt), 1254036-71-9(free base)Description: GSK-2269557 is a potent and selective PI3K.DELTA. inhibitor. GSK-2269557 is is currently in clinical trials for the treatment of respiratory diseases such as asthma and COPD. GSK-2269557 is highly selective for PI3K.DELTA. over the closely related isoforms and are active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation. PI3K.DELTA. is highly enriched in leukocytes, making it an attractive target for the treatment of inflammatory conditions, such as asthma,6 chronic obstructive pulmonary disease (COPD), and autoimmune diseases. (last updated: 9/3/2015). | ||
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CHEMBL3545250
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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100000175665
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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II4WQU7U3O
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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49784084
Created by
admin on Tue Apr 01 17:10:09 GMT 2025 , Edited by admin on Tue Apr 01 17:10:09 GMT 2025
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ACTIVE MOIETY
SUBSTANCE RECORD
