Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H8O3 |
Molecular Weight | 140.1366 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(O)C(O)=CC=C1
InChI
InChIKey=LPYUENQFPVNPHY-UHFFFAOYSA-N
InChI=1S/C7H8O3/c1-10-6-4-2-3-5(8)7(6)9/h2-4,8-9H,1H3
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium. | 1990 Sep |
|
Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. | 2001 Feb |
|
Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol. | 2008 Jul 15 |
|
Oxidative stress and vascular function: implications for pharmacologic treatments. | 2010 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8416747
Multi-organ cancer was induced in rats by application of 100 mg/kg of body weight diethylnitrosamine intraperitoneal injection, 4 times intraperitoneal injection of 20 mg/kg of body weight N-methylnitrosourea, 4 times subcutaneous injection of 40 mg/kg of body weight dimethylhydrazine, 0.05% oral N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water for the first 2 weeks and 0.1% oral 2,2'-dihydroxy-di-n-propylnitrosamine in the drinking water for the next 2 weeks. Starting 3 days after completion of these carcinogen treatments animals were given diets containing 2% butylated hydroxyanisole, 0.8% catechol, 2% 3-methoxycatechol, or basal diet either alone or in combination with 0.3% sodium nitrite until week 28 when a complete autopsy was performed. The combination of NaNO2 with 3-methoxycatechol inhibited glandular stomach lesions with or without carcinogen exposure. However, 3-Methoxycatechol promoted esophageal carcinogenesis either with or without NaNO2.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15135085
Hepatocytes were isolated from rats by collagenase perfusion of the liver. Isolated hepatocytes were suspended in Krebs-Henseleit buffer (pH 7.4) containing HEPES (12.5 mM) in continuous rotation at 37 deg-C under a 5% CO2 atmosphere. After 30 min an aliquot of 3-methoxycatechol was added and the hepatocytes were incubated for another 2 hours. The concentration at which the compound caused 50% cell death was determined by counting the number of cells that excluded trypan blue. 3-methoxychatechol demonstrated an LD50 of 240 micro-M after 2 hours.
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
141700
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
934-00-9
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
13622
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
DTXSID4020826
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
C066344
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
IC13U5393C
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
66525
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY | |||
|
213-276-4
Created by
admin on Fri Dec 15 19:13:59 GMT 2023 , Edited by admin on Fri Dec 15 19:13:59 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD