Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H13NO2 |
Molecular Weight | 167.205 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)OC1(CCCCC1)C#C
InChI
InChIKey=GXRZIMHKGDIBEW-UHFFFAOYSA-N
InChI=1S/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)
Ethinamate was used to treat insomnia (trouble in sleeping) under the brand name VALMID, but then was replaced by other more efficacy medicines. The mechanism of action was not known. However, was studies, which showed that ethinamate inhibits carbonic anhydrases I and did not inhibit II. Nevertheless, even inhibition carbonic anhydrases I is not sufficiently strong to implicate carbonic anhydrases I in the mechanism of action.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P00915 Gene ID: 759.0 Gene Symbol: CA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1460006 |
2.9 mM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | valmid Approved UseUnknown |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
5.9 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4604053 |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
ETHINAMATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
2.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4604053 |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
ETHINAMATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED |
Doses
Dose | Population | Adverse events |
---|---|---|
15 g single, oral Overdose |
healthy, 24 years n = 1 Health Status: healthy Age Group: 24 years Sex: M Population Size: 1 Sources: |
Other AEs: Breathing slowed... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Breathing slowed | 1 patient | 15 g single, oral Overdose |
healthy, 24 years n = 1 Health Status: healthy Age Group: 24 years Sex: M Population Size: 1 Sources: |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/mmx/ethinamate.html
single oral dose of 1 gram
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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DEA NO. |
2545
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NCI_THESAURUS |
C29756
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C100198
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549
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C65559
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126-52-3
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24474
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7325
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CHEMBL1576
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SUB07276MIG
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ETHINAMATE
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3284
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11538
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DB01031
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4884
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204-789-4
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1081
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M1137
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3325
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IAN371PP48
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DTXSID7023013
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ACTIVE MOIETY