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Details

Stereochemistry ACHIRAL
Molecular Formula C9H13NO2
Molecular Weight 167.205
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHINAMATE

SMILES

NC(=O)OC1(CCCCC1)C#C

InChI

InChIKey=GXRZIMHKGDIBEW-UHFFFAOYSA-N
InChI=1S/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)

HIDE SMILES / InChI

Description

Ethinamate was used to treat insomnia (trouble in sleeping) under the brand name VALMID, but then was replaced by other more efficacy medicines. The mechanism of action was not known. However, was studies, which showed that ethinamate inhibits carbonic anhydrases I and did not inhibit II. Nevertheless, even inhibition carbonic anhydrases I is not sufficiently strong to implicate carbonic anhydrases I in the mechanism of action.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
2.9 mM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
valmid

Cmax

ValueDoseCo-administeredAnalytePopulation
5.9 μg/mL
1 g single, oral
ETHINAMATE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
2.3 h
1 g single, oral
ETHINAMATE plasma
Homo sapiens

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
single oral dose of 1 gram
Route of Administration: Oral
In Vitro Use Guide
Unknown