AB-FUBINACA

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H21FN4O2
Molecular Weight	368.4047
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC(C)[C@H](NC(=O)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3)C(N)=O

InChI

InChIKey=AKOOIMKXADOPDA-KRWDZBQOSA-N

InChI=1S/C20H21FN4O2/c1-12(2)17(19(22)26)23-20(27)18-15-5-3-4-6-16(15)25(24-18)11-13-7-9-14(21)10-8-13/h3-10,12,17H,11H2,1-2H3,(H2,22,26)(H,23,27)/t17-/m0/s1

HIDE SMILES / InChI

Description

AB‐FUBINACA is a synthetic cannabinoid and it is a very potent agonist for the cannabinoid (CB1) receptor. AB-FUBINACA is designated as a Schedule I controlled substance in the United States.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85	Agonist 2,678		2.1 nM [EC50]
Cannabinoid CB1 receptor 85	Agonist 2,678		0.9 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,578

PubMed

Show entries

Title	Date	PubMed
UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome.	2014 Jun	24861751
Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market.	2015 Aug	26061356
Synthetic cannabimimetic agents metabolized by carboxylesterases.	2015 Jul	25346527
Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA.	2015 Sep 16	26134475
Schedules of Controlled Substances: Placement of PB-22, 5F-PB-22, AB-FUBINACA and ADB-PINACA into Schedule I. Final rule.	2016 Sep 6	27632803

Showing 1 to 5 of 5 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

AB‐FUBINACA is a very potent ligand for the cannabinoid (CB1) receptor, with a Ki of 0.9 nM and an EC50 of 23.2 nM for receptor activation as measured by GTPgammaS hydrolysis.

Show entries

Name

Type

Language

AB-FUBINACA

Common Name

English

N-((1S)-1-(AMINOCARBONYL)-2-METHYLPROPYL)-1-((4-FLUOROPHENYL)METHYL)-1H-INDAZOLE-3-CARBOXAMIDE

Systematic Name

English

DEA NO. 7012

Code