| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H24O9 |
| Molecular Weight | 372.3671 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(\C=C\CO)=CC(OC)=C1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
InChI
InChIKey=QJVXKWHHAMZTBY-GCPOEHJPSA-N
InChI=1S/C17H24O9/c1-23-10-6-9(4-3-5-18)7-11(24-2)16(10)26-17-15(22)14(21)13(20)12(8-19)25-17/h3-4,6-7,12-15,17-22H,5,8H2,1-2H3/b4-3+/t12-,13-,14+,15-,17+/m1/s1
Syringin is a compound, extracted from Eleutherococcus senticosus. It is a component of herbs, which are used in traditional Chinese medicine. Several studies have demonstrated the multiple pharmacological properties of syringin, including anti-inflammatory, anti-tumor, and immunomodulatory effect. It was tested in several preclinical studies against type 2 diabetes, cardiac hypertrophy, edema, and arthritis. Syringin was shown to inhibit ICAM-1 expression and is considered as a possible treatment for acute gout.
Originator
Approval Year
PubMed
Sample Use Guides
In a preclinical study, diabetic mice were given an every-other-day intraperitoneal injection of syringin (5 mg/kg. In another study, mice with cardiac hypertrophy were gavaged with syringin at
doses of 50 mg/kg body weight (L-syringin) or 100 mg/kg body weight (syringin) for 7 weeks.
Route of Administration:
Other
Murine RAW264.7 macrophages (10(6) cells/ml) were stimulated by LPS (1 ug/ml) in presence of syringin at concentrations of 62.5, 125, 250, 500, 1000 uM for 6 (TNF-alpha production assay) or 24 h (NO production assay). To study the effect of syringin on CD4+T lymphocyte proliferation, splenocytes (5*10(6) cells/mL) were incubated with various concentrations of the drug (62.5, 125, 250, 500, 1000 uM) in the presence of Con A (1ug/ml) for 48 h. In order to test the effect of syringin on CTLL-2 proliferation stimulated by 25 IU/ml of IL-2, the cells (5*10(5) cells/mL) were incubated with the same range of concentrations of syringin in the presence of 25 IU/mL of IL-2 for 48 h.
SUBSTANCE RECORD
