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Details

Stereochemistry RACEMIC
Molecular Formula C9H11ClO3
Molecular Weight 202.635
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORPHENESIN

SMILES

OCC(O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=MXOAEAUPQDYUQM-UHFFFAOYSA-N
InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2

HIDE SMILES / InChI

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1271399 | https://www.ncbi.nlm.nih.gov/pubmed/24628968 | https://www.ncbi.nlm.nih.gov/pubmed/2941223 |

Chlorphenesin is a preservative and cosmetic biocide that helps prevent the growth of microorganisms. In cosmetics and personal care products, Chlorphenesin is used in the formulation of aftershave lotions, bath products, cleansing products, deodorants, hair conditioners, makeup, skin care products, personal cleanliness products, and shampoos. Chlorphenesin has been reported to cause irritation and contact dermatitis in some people, particularly those with sensitive and dry skin. The Cosmetic Ingredient Review (CIR) expert panel released a safety assessment in October 2012, however, that stated chlorphenesin at 0.3 percent (as it exists in personal care products) was classified as having “negligible dermal irritation potential.”

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Volu-Firm

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin.
1971 Aug
Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.
1984 Sep
Medical treatment of the major neuralgias.
1988 Dec
Patents

Patents

Sample Use Guides

The ingredient is allowed at up to 0.3 percent in cosmetic products in the U.S. and Europe.
Route of Administration: Topical
In Vitro Use Guide
The action of chlorphenesin on histamine release was investigated with isolated human leukocytes. Cells from ragweed or grass pollen sensitive donors were added to tubes containing a variable concentration of the chlorphenesin (2*10^-4-1*10^-3 M) and a constant concentration of ragweed antigen E or rye grass Group I antigen which was sufficient for 60% to 80% histamine release. A chlorphenesin concentration of between 0.3 and 0.6 mM causes 50 % inhibition.
Name Type Language
CHLORPHENESIN
INCI   INN   MART.   MI   VANDF   WHO-DD  
INN   INCI  
Official Name English
CHLORPHENESIN [MART.]
Common Name English
CHLORPHENESIN [MI]
Common Name English
Chlorphenesin [WHO-DD]
Common Name English
chlorphenesin [INN]
Common Name English
CHLORPHENESIN [VANDF]
Common Name English
NSC-6401
Code English
CHLORPHENESIN [INCI]
Common Name English
Classification Tree Code System Code
WHO-ATC D01AE07
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
WHO-VATC QD01AE07
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
Code System Code Type Description
DRUG BANK
DB00856
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PRIMARY
NCI_THESAURUS
C77041
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NSC
6401
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PRIMARY
RXCUI
2399
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EPA CompTox
DTXSID0049028
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EVMPD
SUB06202MIG
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PRIMARY
CHEBI
3642
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FDA UNII
I670DAL4SZ
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MESH
D002743
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INN
825
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CAS
104-29-0
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SMS_ID
100000081871
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DAILYMED
I670DAL4SZ
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
PRIMARY
CHEBI
59480
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
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PUBCHEM
7697
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
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ECHA (EC/EINECS)
203-192-6
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
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ChEMBL
CHEMBL607710
Created by admin on Fri Dec 15 16:33:29 GMT 2023 , Edited by admin on Fri Dec 15 16:33:29 GMT 2023
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MERCK INDEX
m3454
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PRIMARY Merck Index