Details
Stereochemistry | RACEMIC |
Molecular Formula | C9H11ClO3 |
Molecular Weight | 202.635 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(O)COC1=CC=C(Cl)C=C1
InChI
InChIKey=MXOAEAUPQDYUQM-UHFFFAOYSA-N
InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/1271399 | https://www.ncbi.nlm.nih.gov/pubmed/24628968 | https://www.ncbi.nlm.nih.gov/pubmed/2941223 |
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/1271399 | https://www.ncbi.nlm.nih.gov/pubmed/24628968 | https://www.ncbi.nlm.nih.gov/pubmed/2941223 |
Chlorphenesin is a preservative and cosmetic biocide that helps prevent the growth of microorganisms. In cosmetics and personal care products, Chlorphenesin is used in the formulation of aftershave lotions, bath products, cleansing products, deodorants, hair conditioners, makeup, skin care products, personal cleanliness products, and shampoos. Chlorphenesin has been reported to cause irritation and contact dermatitis in some people, particularly those with sensitive and dry skin. The Cosmetic Ingredient Review (CIR) expert panel released a safety assessment in October 2012, however, that stated chlorphenesin at 0.3 percent (as it exists in personal care products) was classified as having “negligible dermal irritation potential.”
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0001821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4186918 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Inactive ingredient | Volu-Firm Approved UseUnknown |
Sample Use Guides
The ingredient is allowed at up to 0.3 percent in cosmetic products in the U.S. and Europe.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4186918
The action of chlorphenesin on histamine release was investigated with isolated human leukocytes. Cells from ragweed or grass pollen sensitive donors were added to tubes containing a variable concentration of the chlorphenesin (2*10^-4-1*10^-3 M) and a constant concentration of ragweed antigen E or rye grass Group I antigen which was sufficient for 60% to 80% histamine release. A chlorphenesin concentration of between 0.3 and 0.6 mM causes 50 % inhibition.
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WHO-ATC |
D01AE07
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NCI_THESAURUS |
C28394
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WHO-VATC |
QD01AE07
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m3454
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ACTIVE MOIETY