ROMERGOLINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H22N4O2
Molecular Weight	350.4143
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@@H](CN5CC(=O)NC(=O)C5)CN2C

InChI

InChIKey=RJCXNCSJGRUWRW-SJKOYZFVSA-N

InChI=1S/C20H22N4O2/c1-23-8-12(9-24-10-18(25)22-19(26)11-24)5-15-14-3-2-4-16-20(14)13(7-21-16)6-17(15)23/h2-5,7,12,17,21H,6,8-11H2,1H3,(H,22,25,26)/t12-,17-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1681087 | https://www.ncbi.nlm.nih.gov/pubmed/8723141 | https://adisinsight.springer.com/drugs/800001388

Romergoline (FCE 23884) is an ergoline derivative and a dopamine receptor agonist and antagonist. Its action depends on the functional state of the biological substrate, mostly related to the presence or absence of dopamine. In healthy animals, it behaves as a full dopamine antagonist, but in denervated models it behaves as an agonist. Therefore, romergoline was suggested to be potentially useful in both psychotic states and extrapyramidal diseases. In Parkinson patients, the degree of dopamine receptor stimulation was found to be insufficient to improve symptoms. Information about further development of romergoline is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of the putative dopamine D1 agonist and D2 antagonist FCE 23884 on Parkinson's disease.	1996 May	8723141

Patents

Name

Type

Language

ROMERGOLINE

Official Name

English

4-((9,10-DIDEHYDRO-6-METHYLERGOLIN-8B-YL)METHYL)-2,6-PIPERAZINEDIONE

Common Name

English

romergoline [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884