Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H22O9 |
| Molecular Weight | 358.3405 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]3(O[C@@H]1OC=C2C(=O)OCC[C@@]2([H])[C@H]1C=C)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O
InChI
InChIKey=VSJGJMKGNMDJCI-ZASXJUAOSA-N
InChI=1S/C16H22O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2,6-8,10-13,15-20H,1,3-5H2/t7-,8+,10-,11-,12+,13-,15+,16+/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23201331
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23201331
Sweroside (or (-)-Sweroside) is a bioactive herbal ingredient isolated from Fructus Corni, which has been widely used for the treatment of osteoporosis in traditional Chinese medicine. Unfortunately, the working mechanisms of this compound are difficult to determine and thus remain unclear. Sweroside has shown anti-inflammatory and analgesic activities. Recently was found that sweroside attenuates α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury in mice by restoring bile acid synthesis and transport to their normal levels, as well as suppressing pro-inflammatory responses. Also has been suggested that sweroside can be a promising osteoporosis therapeutic natural product.
Approval Year
Sample Use Guides
in mice: Mice received sweroside (120 mg·kg(-1)·d(-1), ig) for 5 d
Route of Administration:
Other
It was discovered the potential molecular mechanism of the anti-osteoporotic effect of sweroside on the human MG-63 cells and rat osteoblasts. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test was used to observe the effect of sweroside on cell proliferation. The activity of alkaline phosphatase (ALP) and the amount of osteocalcin were also assayed the cell differentiation. Sweroside significantly increased the proliferation of human MG-63 cells and rat osteoblasts (P<0.01). It increased the activity of ALP, and osteocalcin was also elevated in response to sweroside (P<0.05). Of note, flowcytometer assay showed that sweroside can attenuate and inhibit apoptosis. Sweroside has a direct osteogenic effect on the proliferation and differentiation of cultured human MG-63 cells and rat osteoblasts in vitro.
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14215-86-2
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SUBSTANCE RECORD
