U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C20H27NO2
Molecular Weight 313.4339
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VETRABUTINE

SMILES

COC1=C(OC)C=C(C=C1)C(CCCC2=CC=CC=C2)N(C)C

InChI

InChIKey=HEFVRVOEBZDOJU-UHFFFAOYSA-N
InChI=1S/C20H27NO2/c1-21(2)18(12-8-11-16-9-6-5-7-10-16)17-13-14-19(22-3)20(15-17)23-4/h5-7,9-10,13-15,18H,8,11-12H2,1-4H3

HIDE SMILES / InChI
Vetrabutine is a spasmolytic agent. As a musculotropic spasmolytic agent vatrabutine was reported to act directly on the smooth muscle fibers and to have no neurotropic activity. In pigs, its activity was specific to the uterine body and cervical musculature where it acted on the myometrial cells, sealing off the membrane against the passage of potassium ions, thereby increasing membrane potential and lowering tonus. Vetrabutine was of moderate acute oral toxicity. Vetributine hydrochloride has been used in human medicine as a spasmolytic agent in obstetrics.

Approval Year

Sample Use Guides

Single injection to the sows at the dose of 1.67 mg/kg of body weight
Route of Administration: Intramuscular
Name Type Language
VETRABUTINE
INN   MI   WHO-DD  
INN  
Official Name English
vetrabutine [INN]
Common Name English
N,N-DIMETHYL-.ALPHA.-(3-PHENYLPROPYL)VERATRYLAMINE, (±)-
Common Name English
1-(3,4-DIMETHOXYPHENYL)-1-DIMETHYLAMINO-4-PHENYLBUTANE
Systematic Name English
Vetrabutine [WHO-DD]
Common Name English
VETRABUTIN
Common Name English
MONZAL
Brand Name English
VETRABUTINE [MI]
Common Name English
(±)-N,N-DIMETHYL-.ALPHA.-(3-PHENYLPROPYL)VERATRYLAMINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29698
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
WHO-VATC QG02CA90
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
Code System Code Type Description
FDA UNII
I3E2J32F37
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
INN
4010
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
EVMPD
SUB00046MIG
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
MERCK INDEX
m11438
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C73164
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
SMS_ID
100000079083
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104458
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
EPA CompTox
DTXSID90863262
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
CAS
3735-45-3
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY
PUBCHEM
111122
Created by admin on Sat Dec 16 17:53:46 GMT 2023 , Edited by admin on Sat Dec 16 17:53:46 GMT 2023
PRIMARY