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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H50O5
Molecular Weight 490.715
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of ELDECALCITOL

SMILES

[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)[C@@H](OCCCO)[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O

InChI

InChIKey=FZEXGDDBXLBRTD-AYIMTCTASA-N
InChI=1S/C30H50O5/c1-20(9-6-15-29(3,4)34)24-13-14-25-22(10-7-16-30(24,25)5)11-12-23-19-26(32)28(27(33)21(23)2)35-18-8-17-31/h11-12,20,24-28,31-34H,2,6-10,13-19H2,1,3-5H3/b22-11+,23-12-/t20-,24-,25+,26-,27-,28-,30-/m1/s1

HIDE SMILES / InChI
Eldecalcitol (1α, 25-dihydroxy-2β-[3-hydroxypropyloxy] vitamin D3; ED-71) is an analog of the active form of vitamin D. Eldecalcitol has a hydroxypropyloxy group at the 2β-position of 1,25(OH)2D3. Compared with 1,25(OH)2D3, eldecalcitol has a higher affinity for serum vitamin D-binding protein (DBP), binds more weakly to vitamin D receptor, and shows lower potency in suppression of serum parathyroid hormone. The plasma half-life of eldecalcitol is longer than that of 1,25(OH)2D3, probably due to the higher affinity for DBP. In addition to regulation of calcium metabolism carried out by conventional vitamin D analogs, eldecalcitol possesses a strong inhibitory effect on bone resorption and causes a significant increase in bone mineral density. EDIROL (Eldecalcitol) has been approved for the treatment of osteoporosis in Japan.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
EDIROL

Approved Use

EDIROL (Eldecalcitol) is indicated for the treatment of osteoporosis.

Launch Date

1.29548157E12
PubMed

PubMed

TitleDatePubMed
Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxyalkoxy group at the 2 beta-position.
1993 Jun
A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.
2005 Sep
Eldecalcitol: a review of its use in the treatment of osteoporosis.
2011 Sep 10
Spotlight on eldecalcitol in osteoporosis.
2012 Jan 1
Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials.
2016
Effect of eldecalcitol on articular cartilage through the regulation of transcription factor Erg in a murine model of knee osteoarthritis.
2018 Jan 1
Patents

Sample Use Guides

In general, for adults, take 0.75mcg of EDIROL (Eldecalcitol) once a day. It should be decreased according to your symptoms. 1 capsule contains 0.5mcg of the active ingredient.
Route of Administration: Oral
Gene expression was analyzed in chondrocytes that were isolated from wildtype neonatal mice, cultured, and treated with ED-71 (Eldecalcitol) (10 nM). In primary chondrocytes cultured with ED-71, the gene expression of Erg and lubricin/proteoglycan 4 significantly increased, as compared to that of cells cultured without ED-71.
Name Type Language
ELDECALCITOL
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
Eldecalcitol [WHO-DD]
Common Name English
(5Z,7E)-2.BETA.-(3-HYDROXYPROPOXY)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1.ALPHA.,3.BETA.,25-TRIOL
Common Name English
eldecalcitol [INN]
Common Name English
ED-71
Code English
ELDECALCITOL [MI]
Common Name English
ELDECALCITOL [JAN]
Common Name English
ELDECALCITOL [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C39713
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
Code System Code Type Description
MERCK INDEX
m4857
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY Merck Index
DRUG CENTRAL
5169
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
DRUG BANK
DB05295
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
FDA UNII
I2JP8UE90H
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
WIKIPEDIA
Eldecalcitol
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID901030495
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
CAS
104121-92-8
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
SMS_ID
100000124287
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
IUPHAR
2783
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
PUBCHEM
6918141
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
EVMPD
SUB32360
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
NCI_THESAURUS
C87291
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
CHEBI
73927
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY
INN
8867
Created by admin on Fri Dec 15 16:40:40 UTC 2023 , Edited by admin on Fri Dec 15 16:40:40 UTC 2023
PRIMARY