Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H15ClN2O.ClH |
| Molecular Weight | 347.238 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.ClC1=CC=CC(COC2=C(C=CC=C2)C(=C)N3C=CN=C3)=C1
InChI
InChIKey=LWJUIYYIILPRRI-UHFFFAOYSA-N
InChI=1S/C18H15ClN2O.ClH/c1-14(21-10-9-20-13-21)17-7-2-3-8-18(17)22-12-15-5-4-6-16(19)11-15;/h2-11,13H,1,12H2;1H
Croconazole is a antifungal drug developed for the treatment of dermatomycoses and candidiasis. It has a broad spectrum activity against many microorganisms such as T. mentagrophytes, T. rubrum, M. canis, Microsporum gypseum, and Epidermophyton floccosum. The drug was used as a topical 1% cream under the name Pilzcin. According to the information on the manufacturer (Merz pharma) website, Pilzcin is no longer marketed.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp. | 1992 Apr |
|
| Reptilian chemistry: volatile compounds from paracloacal glands of the American crocodile (Crocodylus acutus). | 2002 Apr |
Patents
Sample Use Guides
One topical application per day (1% cream formulation).
Route of Administration:
Topical
The range of MICs against isolates of T. mentagrophytes, T. rubrum, M. canis, Microsporum gypseum, and Epidermophyton floccosum were 0.16 to 1.25 ug/ml. Five isolates of Aspergillus species and two isolates of Penicillium species were susceptible, with MICs of 0.63 to 5.0 ug/ml. However, this compound was less active (MICs, 10 to 80 ug/ml) against yeast-like fungi, including isolates of C. albicans, Candida species, Torulopsis glabrata, and Cryptococcus neoformans.
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C514
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C038008
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m3850
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C97991
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I0WFH323HZ
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77174-66-4
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ACTIVE MOIETY
SUBSTANCE RECORD
