Glyceryl trierucate (trierucin) is a trierucic acid triglyceride that has been investigated for the treatment of adrenoleukodystrophy, a rare genetic disorder characterized by the breakdown or loss of myelin in the brain. To investigate treatment options for adrenoleukodystrophy, most studies have used “Lorenzo's oil" (LO), a 4:1 mixture of glyceryl trioleate and glyceryltrierucate. Lorenzo’s oil was found to reduce the levels of saturated very long chain fatty acids (ELOVL) in the plasma, adipose tissue and liver, but to a lesser extent in the brain. Inhibition of ELOVL 1 may be an underlying mechanism by which Lorenzo's oil exerts its action. Several clinical trials have been conducted to study the potential of glyceryl trierucate in treatment of adrenoleukodystrophy.