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Details

Stereochemistry ACHIRAL
Molecular Formula C69H128O6
Molecular Weight 1053.751
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 3
Charge 0

SHOW SMILES / InChI
Structure of GLYCERYL TRIERUCATE

SMILES

CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC

InChI

InChIKey=XDSPGKDYYRNYJI-IUPFWZBJSA-N
InChI=1S/C69H128O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-52-55-58-61-67(70)73-64-66(75-69(72)63-60-57-54-51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)65-74-68(71)62-59-56-53-50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,66H,4-24,31-65H2,1-3H3/b28-25-,29-26-,30-27-

HIDE SMILES / InChI
Glyceryl trierucate (trierucin) is a trierucic acid triglyceride that has been investigated for the treatment of adrenoleukodystrophy, a rare genetic disorder characterized by the breakdown or loss of myelin in the brain. To investigate treatment options for adrenoleukodystrophy, most studies have used “Lorenzo's oil" (LO), a 4:1 mixture of glyceryl trioleate and glyceryltrierucate. Lorenzo’s oil was found to reduce the levels of saturated very long chain fatty acids (ELOVL) in the plasma, adipose tissue and liver, but to a lesser extent in the brain. Inhibition of ELOVL 1 may be an underlying mechanism by which Lorenzo's oil exerts its action. Several clinical trials have been conducted to study the potential of glyceryl trierucate in treatment of adrenoleukodystrophy.

Approval Year

Name Type Language
GLYCERYL TRIERUCATE
MART.   VANDF   WHO-DD  
Common Name English
13-DOCOSENOIN, TRI-, (Z,Z,Z)-
Common Name English
TRIERUCIN
INCI  
INCI  
Official Name English
GLYCERYL TRIERUCATE [VANDF]
Common Name English
Glyceryl trierucate [WHO-DD]
Common Name English
ERUCIN, TRI-
Common Name English
TRIERUCIN COMPONENT OF LORENZO'S OIL
Common Name English
LORENZO'S OIL COMPONENT
Common Name English
13-DOCOSENOIC ACID, 1,2,3-PROPANETRIYL ESTER, (Z,Z,Z)-
Common Name English
TRIERUCIN [INCI]
Common Name English
13-DOCOSENOIC ACID, 1,2,3-PROPANETRIYL ESTER, (13Z,13'Z,13''Z)-
Common Name English
TRI(Z-13-DOCOSENOYL)GLYCEROL
Common Name English
GLYCEROL TRIERUCATE
Common Name English
ERUCIC ACID TRIGLYCERIDE
Common Name English
GLYCERYL TRIERUCATE [MART.]
Common Name English
(Z)-13-DOCOSENOIC ACID TRIGLYCERIDE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 87594
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
Code System Code Type Description
SMS_ID
100000078197
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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DRUG BANK
DB12528
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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ECHA (EC/EINECS)
220-399-7
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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EVMPD
SUB13996MIG
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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CAS
2752-99-0
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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PUBCHEM
5463075
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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EPA CompTox
DTXSID401021942
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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FDA UNII
I0IDQ0M20R
Created by admin on Fri Dec 15 19:52:08 GMT 2023 , Edited by admin on Fri Dec 15 19:52:08 GMT 2023
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