E-7386

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C39H48FN9O4
Molecular Weight	725.8547
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1CCN(CC1)C2CN(C2)C3=CC=CC(CN4C[C@H]5N([C@@H](CC6=CC=C(O)C=C6F)C4=O)C(=O)CN(CC=C)N5C(=O)NCC7=CC=CC=C7)=N3

InChI

InChIKey=ZGNKNLOBYFTGRG-GIWKVKTRSA-N

InChI=1S/C39H48FN9O4/c1-3-15-47-27-37(51)48-34(20-29-13-14-32(50)21-33(29)40)38(52)46(26-36(48)49(47)39(53)41-22-28-9-6-5-7-10-28)23-30-11-8-12-35(42-30)45-24-31(25-45)44-18-16-43(4-2)17-19-44/h3,5-14,21,31,34,36,50H,1,4,15-20,22-27H2,2H3,(H,41,53)/t34-,36-/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
canonical Wnt signaling pathway 1 Target ID: GO:0060070 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29786110 \| https://www.cancer.gov/publications/dictionaries/cancer-drug/def/793902 \| https://cancerres.aacrjournals.org/content/77/13_Supplement/5172	Inhibitor 8504

PubMed

Title	Date	PubMed
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).	2018-08	29786110

Sample Use Guides

In Vivo Use Guide

Phase I study. 10, 15 and 20 mg, tablets, orally, twice daily, in 28-days treatment cycle

Route of Administration: Oral

Name

Type

Language

E-7386

Code

English

E7386

Preferred Name

English

E 7386 [WHO-DD]

Common Name

English

2H-PYRAZINO(2,1-C)(1,2,4)TRIAZINE-1(6H)-CARBOXAMIDE, 8-((6-(3-(4-ETHYL-1-PIPERAZINYL)-1-AZETIDINYL)-2-PYRIDINYL)METHYL)-6-((2-FLUORO-4-HYDROXYPHENYL)METHYL)HEXAHYDRO-4,7-DIOXO-N-(PHENYLMETHYL)-2-(2-PROPEN-1-YL)-, (6S,9AS)-

Systematic Name

English

(6S,9AS)-2-ALLYL-N-BENZYL-8-((6-(3-(4-ETHYLPIPERAZIN-1-YL)AZETIDIN-1-YL)PYRIDIN-2-YL)METHYL)-6-(2-FLUORO-4-HYDROXYBENZYL)-4,7-DIOXOHEXAHYDRO-2H-PYRAZINO(2,1-C)(1,2,4)TRIAZINE-1(6H)-CARBOXAMIDE

Systematic Name

English

(6S,9AS)-8-((6-(3-(4-ETHYL-1-PIPERAZINYL)-1-AZETIDINYL)-2-PYRIDINYL)METHYL)-6-((2-FLUORO-4-HYDROXYPHENYL)METHYL)HEXAHYDRO-4,7-DIOXO-N-(PHENYLMETHYL)-2-(2-PROPEN-1-YL)-2H-PYRAZINO(2,1-C)(1,2,4)TRIAZINE-1(6H)-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

SMS_ID

300000003820