U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H27FO5
Molecular Weight 378.4345
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOFLUPREDONE

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=WAIJIHDWAKJCBX-BULBTXNYSA-N
InChI=1S/C21H27FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h5,7,9,14-16,23,25,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

HIDE SMILES / InChI
Isoflupredone is a veterinary drug used in cows, pigs and horses for the treatment of wide range of conditions: ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases, etc. The drug belongs to the class of corticosteroids and exerts its therapeutic effect by binding to glucocorticoid and mineralocorticoid receptors of animals.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
Palliative
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
Primary
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
Curative
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
Palliative
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
Palliative
PREDEF

Approved Use

Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc.

Launch Date

1959
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

The usual intramuscular dose for cattle is 10 to 20 mg, according to the size of the animal and severity of the condition. This dose may be repeated in 12 to 24 hours if indicated. The usual intramuscular dose for horses is 5 to 20 mg repeated as necessary. The usual intramuscular dose for swine is 5 mg for a 300 pound animal.
Route of Administration: Intramuscular
In Vitro Use Guide
Unknown
Name Type Language
ISOFLUPREDONE
INN   MI   WHO-DD  
INN  
Official Name English
Isoflupredone [WHO-DD]
Common Name English
.DELTA.-FLUOROCORTISONE
Common Name English
9.ALPHA.-FLUORO-.DELTA.1-CORTISOL
Common Name English
isoflupredone [INN]
Common Name English
(11.BETA.)-9-FLUORO-11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
Systematic Name English
NSC-12174
Code English
PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17,21-TRIHYDROXY-, (11.BETA.)-
Systematic Name English
9-FLUOROPREDNISOLONE
Common Name English
ISOFLUPREDONE [MI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 524.1484C
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
NCI_THESAURUS C521
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
CFR 21 CFR 524.1484B
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
206-422-3
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
ChEMBL
CHEMBL1608183
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
MERCK INDEX
m6490
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY Merck Index
NSC
12174
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
DRUG BANK
DB11522
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
CAS
338-95-4
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
SMS_ID
100000082810
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
DAILYMED
HYS0B45Z2S
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
EVMPD
SUB08318MIG
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
PUBCHEM
127516
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
WIKIPEDIA
Isoflupredone
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
INN
4007
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
NCI_THESAURUS
C77004
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
RXCUI
1546449
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY RxNorm
MESH
C010958
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
FDA UNII
HYS0B45Z2S
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY
EPA CompTox
DTXSID10100933
Created by admin on Fri Dec 15 15:46:22 GMT 2023 , Edited by admin on Fri Dec 15 15:46:22 GMT 2023
PRIMARY