U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H25BrN4O
Molecular Weight 417.343
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMERGURIDE

SMILES

[H][C@@]12CC3=C(Br)NC4=CC=CC(=C34)C1=C[C@@H](CN2C)NC(=O)N(CC)CC

InChI

InChIKey=SBHNNNRQZGYOAU-YVEFUNNKSA-N
InChI=1S/C20H25BrN4O/c1-4-25(5-2)20(26)22-12-9-14-13-7-6-8-16-18(13)15(19(21)23-16)10-17(14)24(3)11-12/h6-9,12,17,23H,4-5,10-11H2,1-3H3,(H,22,26)/t12-,17+/m0/s1

HIDE SMILES / InChI
Bromerguride is an ergot derivative with dopamine antagonistic activity. Bromerguride has been claimed to bind to 5-HT1A receptors and to have 5-HT agonist properties. The neuropharmacological effects caused by the drug in animals were characterized by a central depressant neuroleptic-like symptomatology; the neuroleptic activity of the Bromerguride being at least in the same order of magnitude as haloperidol.

Approval Year

PubMed

PubMed

TitleDatePubMed
Novel 8 alpha-ergolines with inhibitory and stimulatory effects on prolactin secretion in rats.
1984 Oct 29
Name Type Language
BROMERGURIDE
INN  
INN  
Official Name English
3-(2-BROMO-9,10-DIDEHYDRO-6-METHYLERGOLIN-8.ALPHA.-YL)-1,1-DIETHYLUREA
Systematic Name English
bromerguride [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID70232356
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INN
5470
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WIKIPEDIA
Bromerguride
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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FDA UNII
HX58M2377W
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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PUBCHEM
71266
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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MESH
C039667
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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EVMPD
SUB05911MIG
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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NCI_THESAURUS
C73311
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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SMS_ID
100000088672
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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ChEMBL
CHEMBL2104211
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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CAS
83455-48-5
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
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