Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H16N4O3.2Cl |
| Molecular Weight | 359.208 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].NC(=O)C1=CC=[N+](COC[N+]2=C(\C=N\O)C=CC=C2)C=C1
InChI
InChIKey=QELSIJXWEROXOE-UHFFFAOYSA-N
InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig. | 2016-02-26 |
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| Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase. | 2015-03 |
|
| Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. | 2015-02-03 |
|
| Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. | 2014-11-18 |
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| Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. | 2013-12-15 |
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| In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase. | 2013-03-25 |
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| Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. | 2013-03-25 |
|
| A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | 2013-03-25 |
|
| Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. | 2013-03-25 |
|
| Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. | 2012-03-07 |
|
| Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. | 2011-12-18 |
|
| Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. | 2011-11-15 |
|
| A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice. | 2011-10 |
|
| Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6. | 2011-09-25 |
|
| Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures. | 2011-09-25 |
|
| Increasing oxime efficacy by blood-brain barrier modulation. | 2011-09-25 |
|
| Amidine-oximes: reactivators for organophosphate exposure. | 2011-05-12 |
|
| In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity. | 2011-03-05 |
|
| Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes. | 2011-03 |
|
| Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase. | 2011-01-15 |
|
| In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. | 2011 |
|
| Prediction of soman-induced cerebral damage by distortion product otoacoustic emissions. | 2010-11-09 |
|
| Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation. | 2010-09-06 |
|
| Interactions of pyridinium oximes with acetylcholinesterase. | 2010-09-06 |
|
| Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. | 2010-09-06 |
|
| In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs. | 2010-09-06 |
|
| Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo. | 2010-09-06 |
|
| Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? | 2010-09-06 |
|
| Mechanism for potent reactivation ability of H oximes analyzed by reactivation kinetic studies with cholinesterases from different species. | 2010-09-06 |
|
| Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon. | 2010-05-04 |
|
| Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro. | 2009-08-14 |
|
| Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study. | 2009-06-01 |
|
| In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048. | 2009-06 |
|
| Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. | 2009-04-28 |
|
| Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. | 2008-10-19 |
|
| Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases. | 2008-09-25 |
|
| A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats. | 2008-09-25 |
|
| New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning. | 2008-09-25 |
|
| Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. | 2006-04-14 |
|
| Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos. | 2000-01-14 |
|
| Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. | 1996 |
|
| Spontaneous and oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates. | 1988 |
Patents
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| Code System | Code | Type | Description | ||
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HUV88P6SJS
Created by
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C022870
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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ASOXIME CHLORIDE
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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m2095
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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PRIMARY | Merck Index | ||
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DTXSID101029616
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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34433-31-3
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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91614
Created by
admin on Mon Mar 31 19:43:57 GMT 2025 , Edited by admin on Mon Mar 31 19:43:57 GMT 2025
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SUBSTANCE RECORD
