Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2C7H10NO7P2.2Na.5H2O |
Molecular Weight | 700.2646 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.O.O.[Na+].[Na+].OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O)([O-])=O.OC(CC2=CN=CC=C2)(P(O)(O)=O)P(O)([O-])=O
InChI
InChIKey=HYFDYHPNTXOPPO-UHFFFAOYSA-L
InChI=1S/2C7H11NO7P2.2Na.5H2O/c2*9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;;;;;;;/h2*1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);;;5*1H2/q;;2*+1;;;;;/p-2
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.drugs.com/mtm/risedronate.html
http://www.wikidoc.org/index.php/Risedronate
http://www.rxlist.com/actonel-drug.htm
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/mtm/risedronate.html
http://www.wikidoc.org/index.php/Risedronate
http://www.rxlist.com/actonel-drug.htm
Risedronic acid is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. It is FDA approved for the treatment of postmenopausal osteoporosis, osteoporosis in men, glucocorticoid-induced osteoporosis and Paget’s disease. Calcium, antacids, or oral medications containing divalent cations interfere with the absorption of Risedronic acid. Common adverse reactions include rash, abdominal pain, constipation, diarrhea, indigestion, nausea, backache, urinary tract infectious disease and influenza-like illness.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Hydroxyapatite crystals Sources: https://www.ncbi.nlm.nih.gov/pubmed/25568655 |
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Target ID: CHEMBL1782 |
3.9 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | ACTONEL Approved UseACTONEL is indicated for the treatment and prevention of osteoporosis and Paget’s disease of bone in men and women. Launch Date1998 |
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Primary | ACTONEL Approved UseACTONEL is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of ≥ 7.5 mg prednisone or equivalent) for chronic diseases. Launch Date1998 |
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Primary | ACTONEL Approved UseACTONEL is indicated for treatment of Paget’s disease of bone in men and women. Launch Date1998 |
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Primary | ACTONEL Approved UseACTONEL is indicated for treatment to increase bone mass in men with osteoporosis. Launch Date1998 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
2.05 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521 |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
RISEDRONATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
6.49 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521 |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
RISEDRONATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.61 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/14999521 |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
RISEDRONATE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Doses
Dose | Population | Adverse events |
---|---|---|
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.362 |
unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: Page: p.362 |
Disc. AE: Skin rash, Gastrointestinal upset... AEs leading to discontinuation/dose reduction: Skin rash (1.7%) Sources: Page: p.362Gastrointestinal upset (1.7%) |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 613 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 613 Sources: Page: p.9 |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (0.3%) Sources: Page: p.9 |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: Page: p.9 |
Disc. AE: Vomiting... AEs leading to discontinuation/dose reduction: Vomiting (0.2%) Sources: Page: p.9 |
75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: Page: p.9 |
Disc. AE: Vomiting, Diarrhea... AEs leading to discontinuation/dose reduction: Vomiting (1%) Sources: Page: p.9Diarrhea (1%) |
150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: Page: p.10 |
unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: Page: p.10 |
Disc. AE: Abdominal pain upper, Diarrhea... AEs leading to discontinuation/dose reduction: Abdominal pain upper (2.5%) Sources: Page: p.10Diarrhea (0.8%) Vomiting (0.3%) |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.10 |
unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: Page: p.10 |
Disc. AE: Abdominal pain upper, Vomiting... AEs leading to discontinuation/dose reduction: Abdominal pain upper (1.4%) Sources: Page: p.10Vomiting (0.3%) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Gastrointestinal upset | 1.7% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.362 |
unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: Page: p.362 |
Skin rash | 1.7% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.362 |
unhealthy, 41.6±15.7 n = 60 Health Status: unhealthy Condition: Glucocorticoid-induced bone mineral density loss prevention Age Group: 41.6±15.7 Sex: M+F Population Size: 60 Sources: Page: p.362 |
Diarrhea | 0.3% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 613 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 613 Sources: Page: p.9 |
Vomiting | 0.2% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: Page: p.9 |
Diarrhea | 1% Disc. AE |
75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: Page: p.9 |
Vomiting | 1% Disc. AE |
75 mg 1 times / day multiple, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: multiple Dose: 75 mg, 1 times / day Sources: Page: p.9 |
unhealthy, 50 - 86 n = 616 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 86 Sex: F Population Size: 616 Sources: Page: p.9 |
Vomiting | 0.3% Disc. AE |
150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: Page: p.10 |
unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: Page: p.10 |
Diarrhea | 0.8% Disc. AE |
150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: Page: p.10 |
unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: Page: p.10 |
Abdominal pain upper | 2.5% Disc. AE |
150 mg 1 times / month multiple, oral Recommended Dose: 150 mg, 1 times / month Route: oral Route: multiple Dose: 150 mg, 1 times / month Sources: Page: p.10 |
unhealthy, 50 - 88 n = 650 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 650 Sources: Page: p.10 |
Vomiting | 0.3% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.10 |
unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: Page: p.10 |
Abdominal pain upper | 1.4% Disc. AE |
5 mg 1 times / day multiple, oral Recommended Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.10 |
unhealthy, 50 - 88 n = 642 Health Status: unhealthy Condition: Postmenopausal osteoporosis Age Group: 50 - 88 Sex: F Population Size: 642 Sources: Page: p.10 |
PubMed
Title | Date | PubMed |
---|---|---|
Consensus statement on the modern therapy of Paget's disease of bone from a Western Osteoporosis Alliance symposium. Biannual Foothills Meeting on Osteoporosis, Calgary, Alberta, Canada, September 9-10, 2000. | 2001 Apr |
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Osteoporosis in children and adolescent girls: case report of idiopathic juvenile osteoporosis and review of the literature. | 2001 Aug |
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Risedronate for the prevention and treatment of postmenopausal osteoporosis: results from recent clinical trials. | 2001 Dec |
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Review of risedronate in the treatment of osteoporosis. | 2001 Dec |
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Anabolic agents for treating postmenopausal osteoporosis. | 2001 Dec |
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[Therapy of osteoporosis. Risk factors alone are not an indication]. | 2001 Dec 6 |
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Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. | 2001 Feb |
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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. | 2001 Feb |
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Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. | 2001 Feb 1 |
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Comparison insight dual X-ray absorptiometry (DXA), histomorphometry, ash weight, and morphometric indices for bone evaluation in an animal model (the orchidectomized rat) of male osteoporosis. | 2001 Jan |
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[Fluorides and bisphosphonates in the treatment of osteoporosis]. | 2001 Jul |
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Role of bisphosphonates and calcitonin in the prevention and treatment of osteoporosis. | 2001 Jul |
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[Bisphosphonate treatment prevents hip fractures in 70-79 year old women with osteoporotic vertebral fractures]. | 2001 Jul 14 |
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Re: Lanza et al.--Endoscopic comparison of alendronate and risedronate. | 2001 Jun |
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Hip fractures: do preventive drugs work for all? | 2001 Mar |
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Once-a-week alendronate (Fosamax). | 2001 Mar 19 |
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Effect of combined risedronate and hormone replacement therapies on bone mineral density in postmenopausal women. | 2001 May |
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Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. | 2001 May |
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[Bisphosphonates in osteoporosis. Significantly reduces risk of fracture]. | 2001 May 3 |
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The effect of risedronate on the risk of hip fracture in elderly women. | 2001 May 31 |
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The effect of risedronate on the risk of hip fracture in elderly women. | 2001 May 31 |
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A method to assess the proportion of treatment effect explained by a surrogate endpoint. | 2001 Nov 15 |
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Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. | 2001 Oct |
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Risedronate: a new oral bisphosphonate. | 2001 Sep |
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Bisphosphonates for osteoporosis. | 2001 Sep |
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Pharmacologic therapy for the treatment and prevention of osteoporosis. | 2001 Sep |
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Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates. | 2001 Sep 1 |
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Effect of vitamin D on bone mineral density of elderly patients with osteoporosis responding poorly to bisphosphonates. | 2002 |
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[Osteoporosis - Evidence based therapy]. | 2002 Apr |
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Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint. | 2002 Feb |
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Therapies to improve bone mineral density and reduce the risk of fracture: clinical trial results. | 2002 Jan |
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Activity of bisphosphonates against Trypanosoma brucei rhodesiense. | 2002 Jul 4 |
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Gateways to clinical trials. | 2002 May |
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Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date. | 2002 May 28 |
|
The potential of parathyroid hormone as a therapy for osteoporosis. | 2002 May-Jun |
Patents
Sample Use Guides
Treatment of Postmenopausal Osteoporosis: 5 mg daily, 35 mg once-a-week, 75 mg two consecutive days each month, 150 mg once-a-month.
Prevention of Postmenopausal Osteoporosis: 5 mg daily, 35 mg once-a-week.
Men with Osteoporosis: 35 mg once-a-week.
Glucocorticoid-Induced Osteoporosis: 5 mg daily.
Paget’s Disease: 30 mg daily for 2 month.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21357292
The antimalarial activities of risedronate, one of the most potent bisphosphonates clinically used to treat bone resorption diseases, against blood stages of Plasmodium falciparum (50% inhibitory concentration [IC50] of 20.3±1.0 μM).
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HU2YAQ274O
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11954322
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SUB26270
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ACTIVE MOIETY
SUBSTANCE RECORD