Details
Stereochemistry | RACEMIC |
Molecular Formula | C22H29N3S2.2C4H6O5 |
Molecular Weight | 667.791 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CC(O)=O)C(O)=O.OC(CC(O)=O)C(O)=O.CCSC1=CC2=C(SC3=C(C=CC=C3)N2CCCN4CCN(C)CC4)C=C1
InChI
InChIKey=GTHHLZDYRHLACN-UHFFFAOYSA-N
InChI=1S/C22H29N3S2.2C4H6O5/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-2(4(8)9)1-3(6)7/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*2,5H,1H2,(H,6,7)(H,8,9)
Thiethylperazine is a antiemetic, which was used for the treatment of nausea and vomiting in patients undergoing radiotherapy, chemotherapy or as a postoperative care. Thiethylperazine exerts its therapeutic effect by blocking dopamine receptors in brain. The drug is capable of potentiating CNS depressants as well as atropine.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date1961 |
|||
Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date1961 |
Doses
Dose | Population | Adverse events |
---|---|---|
100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
Other AEs: Dystonia, Hyperreflexia... |
150 mg 6 times / day multiple, oral (max) Highest studied dose Dose: 150 mg, 6 times / day Route: oral Route: multiple Dose: 150 mg, 6 times / day Sources: |
unhealthy, 22-53 n = 10 Health Status: unhealthy Condition: schizophrenia Age Group: 22-53 Sex: M+F Population Size: 10 Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Dystonia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
|
Hyperreflexia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Thiethylperazine (Torecan)-associated dystonic reactions in children. | 1979 Dec |
|
Dystonic reactions following thiethylperazine in children. | 1982 Oct |
|
Chronic hemidystonia following acute dystonic reaction to thiethylperazine. | 1991 Jun |
|
[Dyskinesis after a single dose of thiethylperazine during the first trimester of pregnancy]. | 1994 Feb 21-28 |
|
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. | 1997 Sep |
|
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. | 2001 Jul 7 |
|
Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. | 2003 May |
|
Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. | 2004 Oct |
|
Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine. | 2005 Aug |
|
Drug treatment during pregnancy and isolated orofacial clefts in hungary. | 2007 Mar |
|
High-degree atrioventricular block in acute ethanol poisoning: a case report. | 2009 Sep 9 |
|
Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. | 2010 Aug |
|
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. | 2011 Oct |
Patents
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C29710
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
||
|
NCI_THESAURUS |
C740
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
257-780-2
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
HP46XK89XB
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
DBSALT001328
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
SUB126078
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
32216
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
C66598
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
CHEMBL1378
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
SUB71452
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
100000151687
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
52239-63-1
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
11954258
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | |||
|
71529
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | RxNorm | ||
|
m10737
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY | Merck Index | ||
|
DTXSID1045586
Created by
admin on Fri Dec 15 16:21:20 GMT 2023 , Edited by admin on Fri Dec 15 16:21:20 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD