VOXVOGANAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H69N11O3
Molecular Weight	788.0799
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C1=C(C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCC2=CC=CC=C2)C3=C(N1)C(=CC(=C3)C(C)(C)C)C(C)(C)C

InChI

InChIKey=ZVOYWSKEBVVLGW-ZDCRTTOTSA-N

InChI=1S/C43H69N11O3/c1-41(2,3)27-23-28-29(35(43(7,8)9)54-34(28)30(24-27)42(4,5)6)25-33(53-36(55)31(44)17-13-20-50-39(45)46)38(57)52-32(18-14-21-51-40(47)48)37(56)49-22-19-26-15-11-10-12-16-26/h10-12,15-16,23-24,31-33,54H,13-14,17-22,25,44H2,1-9H3,(H,49,56)(H,52,57)(H,53,55)(H4,45,46,50)(H4,47,48,51)/t31-,32-,33-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21732630 | https://www.ncbi.nlm.nih.gov/pubmed/23874964 | https://adisinsight.springer.com/drugs/800032182

LTX109 is a synthetic antimicrobial agent and is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. LTX109 was in clinical phase II trials for topical treatment of infections of multiresistant bacterial strains. However, the further development of this drug apparently has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

A Phase I/IIa Study to Evaluate the Safety, Tolerability and Efficacy of Topical LTX-109 in Subjects Nasally Colonized With Methicillin-resistant/-Sensitive Staphylococcus Aureus (MRSA/MSSA). Ascending dose study. Start enrollment to group 1: 1% LTX-109/placebo, then group 2: 2% LTX-109/placebo and finally group 3: 5% LTX-109/placebo dosed in each nostril TID for 3 consecutive days.

Route of Administration: Topical

In Vitro Use Guide

LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus.

Name

Type

Language

VOXVOGANAN

Official Name

English

voxvoganan [INN]

Common Name

English

L-ARGININAMIDE, L-ARGINYL-2,5,7-TRIS(1,1-DIMETHYLETHYL)-L-TRYPTOPHYL-N-(2-PHENYLETHYL)-

Common Name

English

LTX 109 [WHO-DD]

Common Name

English

LTX-109

Code

English

LTX109

Code

English

Code System Code Type Description

FDA UNII

HO813QDF65