Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H24N2O3.ClH |
| Molecular Weight | 328.834 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCC(=O)N2
InChI
InChIKey=FYBXRCFPOTXTJF-MERQFXBCSA-N
InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H/t11-;/m0./s1
(S)-Carteolol is an enantiomer of the racemic drug carteolol, that is used to treat glaucoma. (S) isomer is a partial agonist with the high affinity to the beta-adrenoceptors. It was shown, that in the treatment of glaucoma, the therapeutic advantage of the R(+)-isomers is similar to the S(-)-isomers and there is no stereo-selectivity between the two enantiomers.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of the R(+)- and S(-)-isomers of beta-adrenoceptor blockers with intrinsic sympathomimetic activity, befunolol and carteolol, on rabbit intraocular pressure. | 1991 Aug |
|
| Comparison of interactions of R-(+)- and S-(-)-isomers of beta-adrenergic partial agonists, befunolol and carteolol, with high affinity site of beta-adrenoceptors in isolated rabbit ciliary body and guinea-pig taenia caeci. | 1991 Jul |
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59567-88-3
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HJ5L26N5J9
Created by
admin on Sat Dec 16 10:56:59 GMT 2023 , Edited by admin on Sat Dec 16 10:56:59 GMT 2023
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12285398
Created by
admin on Sat Dec 16 10:56:59 GMT 2023 , Edited by admin on Sat Dec 16 10:56:59 GMT 2023
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SUBSTANCE RECORD
