SULFAMOXOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H13N3O3S
Molecular Weight	267.304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=C(C)N=C(NS(=O)(=O)C2=CC=C(N)C=C2)O1

InChI

InChIKey=CYFLXLSBHQBMFT-UHFFFAOYSA-N

InChI=1S/C11H13N3O3S/c1-7-8(2)17-11(13-7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Description

Sulfamoxole is a sulfonamide antibacterial compound. Sulfamoxole is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Sulfamoxole alone or in combination with trimethoprim is used for the treatment of susceptible infections.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial dihydropteroate synthase	Inhibitor

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections	Curative		Approved	Sulfuno

PubMed

Show entries

Title	Date	PubMed
Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole.	1988 Dec	3237218
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.	1995 Aug	7486915
Determination of some sulfonamides and trimethoprim in chicken, fish muscle and eggs by liquid chromatography-tandem mass spectrometry.	2004 Apr-Jun	20437390
Simultaneous determination of 17 sulfonamides and the potentiators ormetoprim and trimethoprim in salmon muscle by liquid chromatography with tandem mass spectrometry detection.	2007 Jan-Feb	17373466

Showing 1 to 4 of 4 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Adults Dose: Initially 1g to be taken twice daily followed by 500 mg two times a day Child Dose: Initial dose is 50 to 60 mg/kg daily Maximum daily dose is 75mg daily

Route of Administration: Oral

In Vitro Use Guide

sulfamoxole was taken in different doses (500, 1000, 1500, 2000 and 2500 ppm) to test their effectiveness against five pathogenic fungi for the control of mycelial growth and sporulation.

Show entries

Name

Type

Language

SULFAMOXOLE

Official Name

English

NSC-683535

Code

English

BENZENESULFONAMIDE, 4-AMINO-N-(4,5-DIMETHYL-2-OXAZOLYL)-

Systematic Name

English

sulfamoxole [INN]

Common Name

English

SULFAMOXOLE [MI]

Common Name

English

Showing 1 to 5 of 9 entries

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Classification Tree

Code System

Code

Combinations of sulfonamides and trimethoprim, incl. derivatives

WHO-ATC

J01EE04

Intermediate-acting sulfonamides

WHO-ATC

J01EC03

Anti-Infective Agent

NCI_THESAURUS

C29739

Showing 1 to 3 of 3 entries

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Code System

Code

Type

Description

ECHA (EC/EINECS)

211-982-7

PRIMARY

RXCUI

10183

PRIMARY

RxNorm

FDA UNII

HGG82XE020

PRIMARY

CAS

729-99-7

PRIMARY

DRUG BANK

DB08798

PRIMARY

Showing 1 to 5 of 19 entries

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ACTIVE MOIETY


					HGG82XE020

SULFAMOXOLE