U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C22H25NO4.ClH
Molecular Weight 403.899
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PITOFENONE HYDROCHLORIDE

SMILES

Cl.COC(=O)C1=C(C=CC=C1)C(=O)C2=CC=C(OCCN3CCCCC3)C=C2

InChI

InChIKey=ZRFIFDFEDPJBII-UHFFFAOYSA-N
InChI=1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H

HIDE SMILES / InChI
Pitofenone is a spasmolytic agent. It exerts anticholinesterase and antimuscarinic activities. Pitofenone is used to relieve pain and spasms of smooth muscles. Pitofenone is also used for the treatment of back pain, sprains, and strains. Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names. The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation. Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

Approval Year

PubMed

PubMed

TitleDatePubMed
Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.
2004 Jun

Sample Use Guides

The recommended dose of the pitofenone is 50 to 75 mg tablet. Pitofenone is part of an injection which contains 500 mg metamizole sodium, 0.02 mg fenpiverine bromide and 2 mg pitofenone hydrochloride in 1 ml of the solution.
Route of Administration: Other
Name Type Language
PITOFENONE HYDROCHLORIDE
MART.   WHO-DD  
Common Name English
METHYL 2-(4-(2-PIPERIDINOETHOXY)BENZOYL)BENZOATE HYDROCHLORIDE
Systematic Name English
BARALGIN
Brand Name English
PITOFENONE HYDROCHLORIDE [MART.]
Common Name English
PITOPHENONE HYDROCHLORIDE
Common Name English
PITOFENONE HCL
Common Name English
PITOPHENONE HCL
Common Name English
Pitofenone hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
214-999-8
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
PUBCHEM
121097
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
EVMPD
SUB03880MIG
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
FDA UNII
HE1ZA4ZBEX
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
SMS_ID
100000092596
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
CAS
1248-42-6
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID7046461
Created by admin on Fri Dec 15 15:50:44 GMT 2023 , Edited by admin on Fri Dec 15 15:50:44 GMT 2023
PRIMARY