Details
Stereochemistry | ACHIRAL |
Molecular Formula | C13H6ClN5O2 |
Molecular Weight | 299.672 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(=CC2=C1OC3=NC=CC=C3C2=O)C4=NN=NN4
InChI
InChIKey=MLCGWPUVZKTVLO-UHFFFAOYSA-N
InChI=1S/C13H6ClN5O2/c14-9-5-6(12-16-18-19-17-12)4-8-10(20)7-2-1-3-15-13(7)21-11(8)9/h1-5H,(H,16,17,18,19)
Traxanox is a diuretic agent possessing an uricosuric effect in animals. The diuretic and uricosuric effects of the drug have also been demonstrated in normotensive healthy subjects. The chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion. Traxanox sodium stimulates the phagocytic activity of leukocytes or macrophages and prevents the drug-induced suppression of the phagocytic activity of these cells. Traxanox may be clinically effective in treating patients with nasal allergies. The mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis. Also, traxanox may be effective for the treatment of allergic bronchial asthma.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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[General pharmacological actions of traxanox sodium. II. Effects on the cardiovascular system]. | 1983 Jul |
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[Effect of traxanox on antibody formation in C57BL/6 mice]. | 1985 Feb |
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[Effect of traxanox sodium on inflammatory response]. | 1985 Nov |
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[Restorative effect of traxanox on the suppression of antibody production in BALB/c mice]. | 1986 Jan |
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Diuretic and uricosuric effects of traxanox sodium in healthy subjects. Single dose study. | 1987 Dec |
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Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. | 1987 Feb |
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[Effects of traxanox sodium on experimental nasal allergy]. | 1988 Jul |
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Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria. | 1989 |
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Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study. | 1989 Apr |
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Stimulation of phagocytic activity of leukocytes and macrophages by traxanox sodium in mice and rats. | 1989 Feb |
Patents
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NCI_THESAURUS |
C29712
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m11009
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PRIMARY | Merck Index |
ACTIVE MOIETY