Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H22N10O3 |
Molecular Weight | 510.5074 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NN=NN1N=CC2=CC(C(C3=CC=C(O)C=C3)C4=CC(C=NN5N=NN=C5C)=CC=C4O)=C(O)C=C2
InChI
InChIKey=BLUJRJMLDHEMRX-UHFFFAOYSA-N
InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3
VP-14637 (also known as MDT 637) was developed as an inhibitor of respiratory syncytial virus (RSV). RSV is the leading cause of respiratory tract infections in humans. VP-14637 participated in phase I clinical trial to evaluate the safety and pharmacokinetic profile of the drug in healthy human volunteers. However, further study was discontinued because of the strategic decision.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL612679 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25595685 |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT01355016
Inhaled doses of MDT-637 (VP-14637) over a 24 hour period
Route of Administration:
Respiratory
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DTXSID10946228
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135565536
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HCW4G0O030
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DB12195
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SUBSTANCE RECORD