U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C25H22N10O3
Molecular Weight 510.5074
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of VP-14637

SMILES

CC1=NN=NN1N=CC2=CC(C(C3=CC=C(O)C=C3)C4=CC(C=NN5N=NN=C5C)=CC=C4O)=C(O)C=C2

InChI

InChIKey=BLUJRJMLDHEMRX-UHFFFAOYSA-N
InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3

HIDE SMILES / InChI
VP-14637 (also known as MDT 637) was developed as an inhibitor of respiratory syncytial virus (RSV). RSV is the leading cause of respiratory tract infections in humans. VP-14637 participated in phase I clinical trial to evaluate the safety and pharmacokinetic profile of the drug in healthy human volunteers. However, further study was discontinued because of the strategic decision.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
VP-14637 ViroPharma.
2000 Dec
Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms.
2005 Jun

Sample Use Guides

Inhaled doses of MDT-637 (VP-14637) over a 24 hour period
Route of Administration: Respiratory
Name Type Language
VP-14637
Common Name English
PHENOL, 2,2'-((4-HYDROXYPHENYL)METHYLENE)BIS(4-(((5-METHYL-1H-TETRAZOL-1-YL)IMINO)METHYL)-
Common Name English
MDT-637
Common Name English
Code System Code Type Description
CAS
235106-62-4
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
EPA CompTox
DTXSID10946228
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
PUBCHEM
135565536
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
FDA UNII
HCW4G0O030
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
DRUG BANK
DB12195
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY