PROSULPRIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H25N3O4S
Molecular Weight	355.452
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCN1CCCC1CNC(=O)C2=C(OC)C=CC(=C2)S(N)(=O)=O

InChI

InChIKey=SZEAUPPGLDXGJG-UHFFFAOYSA-N

InChI=1S/C16H25N3O4S/c1-3-8-19-9-4-5-12(19)11-18-16(20)14-10-13(24(17,21)22)6-7-15(14)23-2/h6-7,10,12H,3-5,8-9,11H2,1-2H3,(H,18,20)(H2,17,21,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29758 | https://www.ncbi.nlm.nih.gov/pubmed/6107172

Prosulpride is an aminosulfonylbenzamide derivative with potent neuroleptic activity. Prosulpride selectively blocks the presynaptic dopaminergic receptors and antagonize apomorphine-induced stereotyped behavior, circling behavior, climbing behavior, increased motor activity and some other apomorphine-induced effects related to stimulation of postsynaptic dopaminergic receptors.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine receptor 60 Target ID: CHEMBL2096905 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2568417	Antagonist 2778

PubMed

Title	Date	PubMed
Benzamides and classical neuroleptics: comparison of their actions using 6 apomorphine-induced effects.	1978 Aug 15	29758
Definition of the in-vivo binding of [3H]spiperone in rat brain using substituted benzamide drugs.	1989 Feb	2568417

Patents

Sample Use Guides

In Vivo Use Guide

2, 4, and 6 mg/kg

Route of Administration: Other

Name

Type

Language

PROSULPRIDE

Official Name

English

BENZAMIDE, 5-(AMINOSULFONYL)-2-METHOXY-N-((1-PROPYL-2-PYRROLIDINYL)METHYL)-

Systematic Name

English

GRI-1665

Code

English

(±)-N-PROPYLSULPIRIDE

Common Name

English

prosulpride [INN]

Common Name

English

N-PROPYLSULPIRIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883