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Details

Stereochemistry ACHIRAL
Molecular Formula C21H22BrNO
Molecular Weight 384.309
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JWH-249

SMILES

CCCCCN1C=C(C(=O)CC2=C(Br)C=CC=C2)C3=C1C=CC=C3

InChI

InChIKey=CGQRVOHECAULLB-UHFFFAOYSA-N
InChI=1S/C21H22BrNO/c1-2-3-8-13-23-15-18(17-10-5-7-12-20(17)23)21(24)14-16-9-4-6-11-19(16)22/h4-7,9-12,15H,2-3,8,13-14H2,1H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
20.0 nM [Ki]
8.0 nM [IC50]
Name Type Language
JWH-249
Code English
2-(2-BROMOPHENYL)-1-(1-PENTYL-1H-INDOL-3-YL)ETHANONE
Systematic Name English
ETHANONE, 2-(2-BROMOPHENYL)-1-(1-PENTYL-1H-INDOL-3-YL)-
Systematic Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-JWH-249
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
Code System Code Type Description
CAS
864445-60-3
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
PRIMARY
PUBCHEM
44397335
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
PRIMARY
WIKIPEDIA
JWH-249
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
PRIMARY JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB1 with a Ki of 8.4nM +/- 1.8 and 20nM +/- 2 at CB2. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-methyl compound JWH-251, JWH-249 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.
EPA CompTox
DTXSID30658735
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
PRIMARY
FDA UNII
H988KQV4U9
Created by admin on Sat Dec 16 11:17:34 GMT 2023 , Edited by admin on Sat Dec 16 11:17:34 GMT 2023
PRIMARY