Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H22N2O8 |
Molecular Weight | 442.4187 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(OC(=O)C2=C(O)C3=C(O)C=CC=C3C(C)=C12)[C@]4([H])[C@H](O)C(=O)C(C(N)=O)=C(O)[C@H]4N(C)C
InChI
InChIKey=DRKMHDAKULCOKQ-MLZJRGSSSA-N
InChI=1S/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)20(32-22(12)31)13-15(24(2)3)17(27)14(21(23)30)19(29)18(13)28/h4-6,13,15,18,20,25-28H,1-3H3,(H2,23,30)/t13-,15-,18-,20-/m0/s1
alpha-apo-Oxytetracycline is the degradation product of Oxytetracycline. It exhibits greater toxicity compared with the parent compound. No significant differences in body weight were observed between rats in the control group and those in the group treated with alpha-apo-Oxytetracycline. No differences in hematological analyses were observed between rats in the control group and those in the group treated with alpha-apo-Oxytetracycline.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Application of reversed-phase liquid chromatography and prepacked C18 cartridges for the analysis of oxytetracycline and related compounds. | 1996 Mar 3 |
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Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems. | 2003 Jan 5 |
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Characterisation of the abiotic degradation pathways of oxytetracyclines in soil interstitial water using LC-MS-MS. | 2003 Mar |
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Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. | 2008 Jan |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25892782
Rat: 10 mg/kg body weight/day, 90 days
Route of Administration:
Oral
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1361013-47-9
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18695-01-7
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SUBSTANCE RECORD