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Details

Stereochemistry ACHIRAL
Molecular Formula 5Bi.4NO3.O.9HO
Molecular Weight 1461.9871
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BISMUTH SUBNITRATE

SMILES

[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[O--].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=QGWDKKHSDXWPET-UHFFFAOYSA-E
InChI=1S/5Bi.4NO3.9H2O.O/c;;;;;4*2-1(3)4;;;;;;;;;;/h;;;;;;;;;9*1H2;/q5*+3;4*-1;;;;;;;;;;-2/p-9

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/bibrocathol.html | https://clinicaltrials.gov/ct2/show/NCT01357538 | https://www.drugs.com/international/noviform.html | https://www.ncbi.nlm.nih.gov/pubmed/17003947

Bibrocathol (trade names Noviform and Posiformin) is a well-established topical antiseptic for the treatment of acute eyelid diseases like blepharitis. Eye ointments containing 2 or 5 % bibrocathol and the excipients liquid paraffin, white soft paraffin, and lanolin have been marketed since 1967 for the treatment of eye irritation, chronic blepharitis, and uninfected corneal injuries. Reports of clinical experience with bibrocathol for inflammation of the edge of the palpebra exist since the beginning of the 20th century. Until recently, no controlled, randomized clinical studies according to the guidelines for Good Clinical Practice for Trials on Medical Products for Human Use (GCP) as defined by the International Conference on Harmonisation (ICH) have been performed with bibrocathol 2 % ointment, as these were not required for marketing authorization in the 1960s. A first double-blind, prospective, controlled, GCP-compliant clinical study was recently performed to assess the efficacy of bibrocathol 5 % (Noviform®) in acute blepharitis. It demonstrated superior efficacy of bibrocathol 5 % ointment as compared to an ointment vehicle (placebo) after 2 weeks of treatment as assessed by a combined measure of slit-lamp examination results and patients’ subjective complaints.

Originator

Sources: Medizinische Klinik (Muenchen, Germany) (1913), 8, 992.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Noviform

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %).
2012 Dec
Patents

Sample Use Guides

A strip of 5 mm eye ointment applied 3 times per day to the eye lid
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
BISMUTH SUBNITRATE
HSDB   INCI   MART.   MI   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
BISMUTH HYDROXIDE NITRATE OXIDE
Common Name English
BISMUTH SUBNITRATE [INCI]
Common Name English
BISMUTH NITRATE, BASIC
Common Name English
Bismuth hydroxide nitrate oxide [Bi5O(OH)9(NO3)4]
Common Name English
BISMUTH SUBNITRATE, HEAVY
EP  
Common Name English
BISMUTHUM SUBNITRICUM [HPUS]
Common Name English
Bismuth subnitrate [WHO-DD]
Common Name English
BISMUTH SUBNITRATE [MART.]
Common Name English
BISMUTH SUBNITRATE [USP MONOGRAPH]
Common Name English
BISMUTHUM SUBNITRICUM
HPUS  
Common Name English
BISMUTH SUBNITRATE [MI]
Common Name English
BISMUTH SUBNITRATE [VANDF]
Common Name English
BISMUTH SUBNITRATE, HEAVY [EP MONOGRAPH]
Common Name English
C.I. PIGMENT WHITE 17
Common Name English
C.I. 77169
Common Name English
BISMUTH SUBNITRATE [HSDB]
Common Name English
BISMUTH SUBNITRATE [JAN]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 310.531
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
CFR 21 CFR 331.11
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
WHO-ATC A02BX12
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
CFR 21 CFR 331.15
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
NCI_THESAURUS C29701
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
WHO-VATC QA02BX12
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
Code System Code Type Description
DAILYMED
H19J064BA5
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
FDA UNII
H19J064BA5
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID40893872
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PRIMARY
HSDB
1608
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-136-8
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PRIMARY
DRUG BANK
DB13209
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PRIMARY
SMS_ID
100000076850
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PRIMARY
EVMPD
SUB11748MIG
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
NCI_THESAURUS
C76481
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
WIKIPEDIA
Bismuth oxynitrate
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
CAS
1304-85-4
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PRIMARY
MERCK INDEX
m2554
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY Merck Index
EVMPD
SUB13092MIG
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
PUBCHEM
73415757
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
DRUG CENTRAL
4841
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY
RXCUI
19477
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY RxNorm
MESH
C010804
Created by admin on Fri Dec 15 15:00:30 GMT 2023 , Edited by admin on Fri Dec 15 15:00:30 GMT 2023
PRIMARY