U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H22O6
Molecular Weight 310.3423
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TREPIBUTONE

SMILES

CCOC1=CC(OCC)=C(C=C1OCC)C(=O)CCC(O)=O

InChI

InChIKey=YPTFHLJNWSJXKG-UHFFFAOYSA-N
InChI=1S/C16H22O6/c1-4-20-13-10-15(22-6-3)14(21-5-2)9-11(13)12(17)7-8-16(18)19/h9-10H,4-8H2,1-3H3,(H,18,19)

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://www.kegg.jp/medicus-bin/japic_med?japic_code=00054798 http://www.ncbi.nlm.nih.gov/pubmed/864884

This medicine promotes secretion of the bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract (sphincter of hepatopancreatic ampulla etc.) to lower internal pressure of the gallbladder and bile duct. It improves the symptoms of the bile duct and pancreatic disease. It is usually used for improvement of cramp and bile secretion associated with cholelithiasis, cholecystitis, cholangitis, dyskinesia of the biliary tract or postcholecystectomy syndrome, or pain and gastrointestinal symptoms associated with chronic pancreatitis. Side effects are nausea, constipation, abdominal bloating, diarrhea, rash, itch, etc.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
SUPACAL

Approved Use

It is usually used for improvement of cramp and bile secretion associated with cholelithiasis
Palliative
SUPACAL

Approved Use

It is usually used for improvement of cramp and bile secretion associated with cholecystitis
Palliative
SUPACAL

Approved Use

It is usually used for improvement of cramp and bile secretion associated with cholangitis
Palliative
SUPACAL

Approved Use

It is usually used for improvement of cramp and bile secretion associated with postcholecystectomy syndrome
PubMed

PubMed

TitleDatePubMed
pH-independent controlled-release microspheres using polyglycerol esters of fatty acids.
1994 Nov
Patents

Sample Use Guides

1 tablet (40 mg of the active ingredient) 3 times daily, immediately after meal.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
TREPIBUTONE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
Trepibutone [WHO-DD]
Common Name English
TREPIBUTONE [MI]
Common Name English
trepibutone [INN]
Common Name English
3-(2',4',5'-TRIETHOXYBENZOYL)PROPIONIC ACID
Systematic Name English
TREPIBUTONE [JAN]
Common Name English
TREPIBUTONE [MART.]
Common Name English
SUPACAL
Brand Name English
Classification Tree Code System Code
WHO-VATC QA03AX09
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
NCI_THESAURUS C29698
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
WHO-ATC A03AX09
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
Code System Code Type Description
RXCUI
44532
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C66623
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
SMS_ID
100000077483
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
MERCK INDEX
m11017
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Trepibutone
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
DRUG CENTRAL
2719
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
INN
4358
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
CAS
41826-92-0
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID6046634
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL1725880
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
DRUG BANK
DB13311
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
PUBCHEM
5536
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
FDA UNII
H1187LU49Q
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY
EVMPD
SUB11236MIG
Created by admin on Fri Dec 15 16:26:39 GMT 2023 , Edited by admin on Fri Dec 15 16:26:39 GMT 2023
PRIMARY