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Details

Stereochemistry ACHIRAL
Molecular Formula C16H22O6
Molecular Weight 310.3423
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TREPIBUTONE

SMILES

CCOC1=CC(OCC)=C(OCC)C=C1C(=O)CCC(O)=O

InChI

InChIKey=YPTFHLJNWSJXKG-UHFFFAOYSA-N
InChI=1S/C16H22O6/c1-4-20-13-10-15(22-6-3)14(21-5-2)9-11(13)12(17)7-8-16(18)19/h9-10H,4-8H2,1-3H3,(H,18,19)

HIDE SMILES / InChI

Description

This medicine promotes secretion of the bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract (sphincter of hepatopancreatic ampulla etc.) to lower internal pressure of the gallbladder and bile duct. It improves the symptoms of the bile duct and pancreatic disease. It is usually used for improvement of cramp and bile secretion associated with cholelithiasis, cholecystitis, cholangitis, dyskinesia of the biliary tract or postcholecystectomy syndrome, or pain and gastrointestinal symptoms associated with chronic pancreatitis. Side effects are nausea, constipation, abdominal bloating, diarrhea, rash, itch, etc.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
SUPACAL
Palliative
SUPACAL
Palliative
SUPACAL
Palliative
SUPACAL

Cmax

ValueDoseCo-administeredAnalytePopulation
2.9 μg/mL
40 mg single, oral
TREPIBUTONE serum
Homo sapiens
3.6 μg/mL
40 mg single, oral
TREPIBUTONE serum
Homo sapiens
1.4 μg/mL
20 mg single, oral
TREPIBUTONE serum
Homo sapiens
3.1 μg/mL
40 mg single, oral
TREPIBUTONE serum
Homo sapiens
3.9 μg/mL
60 mg single, oral
TREPIBUTONE serum
Homo sapiens
0.3 μg/mL
10 mg single, oral
TREPIBUTONE serum
Homo sapiens
5.1 μg/mL
80 mg single, oral
TREPIBUTONE serum
Homo sapiens
12.1 μg/mL
100 mg single, oral
TREPIBUTONE serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
6.45 μg × h/mL
40 mg single, oral
TREPIBUTONE serum
Homo sapiens
5.1 μg × h/mL
40 mg single, oral
TREPIBUTONE serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.4 h
40 mg single, oral
TREPIBUTONE serum
Homo sapiens
1.79 h
40 mg single, oral
TREPIBUTONE serum
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
6%
TREPIBUTONE serum
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
1 tablet (40 mg of the active ingredient) 3 times daily, immediately after meal.
Route of Administration: Oral
In Vitro Use Guide
Unknown