SEBRIPLATIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H6O4.C5H14N2.Pt
Molecular Weight	439.372
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Pt++].C[C@@H](CN)CCN.[O-]C(=O)C1(CCC1)C([O-])=O

InChI

InChIKey=LQGKRWOLAMMNQG-UTYJZAQGSA-L

InChI=1S/C6H8O4.C5H14N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;1-5(4-7)2-3-6;/h1-3H2,(H,7,8)(H,9,10);5H,2-4,6-7H2,1H3;/q;;+2/p-2/t;5-;/m.1./s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8646805 | https://www.ncbi.nlm.nih.gov/pubmed/8642853 | https://www.ncbi.nlm.nih.gov/pubmed/20593091

Sebriplatin (also known as NK-121 or CI-973) is a platinum analog with antitumor activity. Sebriplatin participated in phase II clinical trials for the treatment of patients with metastatic breast cancer. However, the further development of this drug was discontinued.

Approval Year

PubMed

Title	Date	PubMed
[Effect of a newly developed platinum compound cis-1, 1-cyclobutane dicarboxylato-(2R)-2-methyl-1,4-butane diamine platinum (II), on human ovarian tumors transplanted into nude mice].	1988 Apr	3355185
Comparative cytotoxicity of CI-973, cisplatin, carboplatin and tetraplatin in human ovarian carcinoma cell lines.	1991 May 10	2019469
A phase II study of CI-973 [SP-4-3(R)]-1,1-cyclobutane-dicarboxylato (2-)] (2-methyl-1,4-butanediamine-N, N') platinum in patients with refractory advanced breast cancer.	1996	8646805
Evaluation of CI-973, a platinum analogue, in refractory or relapsed acute leukemia.	1996 Mar	8642853

Sample Use Guides

In Vivo Use Guide

CI-973 (SEBRIPLATIN) was given as a 5-day continuous infusion every 3 to 4 weeks to patients with refractory or relapsed acute leukemia, at doses ranging from 150 mg/m2 to 1350 mg/m2 per course

Route of Administration: Intravenous

Name

Type

Language

SEBRIPLATIN

Official Name

English

PLATINUM, (1,1-CYCLOBUTANEDI(CARBOXYLATO-.KAPPA.O)(2-))((2R)-2-METHYL-1,4-BUTANEDIAMINE-.KAPPA.N1,.KAPPA.N4)-, (SP-4-3)-

Systematic Name

English

(1,1-CYCLOBUTANE-DICARBOXYLATO(2-))(2-METHYL-1,4-BUTANE-DIAMINE-N,N')PLATINUM (SP-4-3-(R))

Common Name

English

SEBRIPLATIN [MART.]

Common Name

English

SEVRIPLATIN

Common Name

English

NK-121

Common Name

English

(+)-CIS-(1,1-CYCLOBUTANEDICARBOXYLATO)((2R)-2-METHYL-1,4-BUTANEDIAMINE-N,N')PLATINUM

Common Name

English

CI-973

Code

English

sebriplatin [INN]

Common Name

English

SEVRIPLATIN [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1450