Brimarafenib

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H17F3N4O4
Molecular Weight	482.4114
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC(F)=C(F)C=C1NC(=O)N[C@@H]2[C@H]3OC4=CC=C(OC5=C6CCC(=O)N=C6NC=C5)C=C4[C@@H]23

InChI

InChIKey=USMWOBMHNWNPAP-FKBYEOEOSA-N

InChI=1S/C24H17F3N4O4/c25-13-8-15(27)16(9-14(13)26)29-24(33)31-21-20-12-7-10(1-3-17(12)35-22(20)21)34-18-5-6-28-23-11(18)2-4-19(32)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,30,32)(H2,29,31,33)/t20-,21-,22-/m0/s1

HIDE SMILES / InChI

Approval Year

Name

Type

Language

Brimarafenib [WHO-DD]

Preferred Name

English

Brimarafenib

Official Name

English

N-{(1S,1aS,6bS)-5-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl}-N?-(2,4,5-trifluorophenyl)urea

Systematic Name

English

Urea, N-[(1S,1aS,6bS)-1a,6b-dihydro-5-[(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-4-yl)oxy]-1H-cyclopropa[b]benzofuran-1-yl]-N?-(2,4,5-trifluorophenyl)-

Systematic Name

English

brimarafenib [INN]

Common Name

English

5-[(2S,3S,4S)-3-[3-(2,4,5-Trifluorophenyl)ureido]-1-oxa-3,4-dihydro-2H-naphth-6-yloxy]-1,8-diaza-4,8-dihydro-2(3H)-naphthalenone

Systematic Name

English

5-[(2S,3S,4S)-3-[3-(2,4,5-trifluorophenyl)urea]-1-oxa-3,4-dihydro-2H-naphthalen-6-yloxy]-1,8-diaza-4,8-dihydronaphthalen-2(3H)-one

Systematic Name

English

N-[(1S,1aS,6bS)-1a,6b-Dihydro-5-[(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-4-yl)oxy]-1H-cyclopropa[b]benzofuran-1-yl]-N?-(2,4,5-trifluorophenyl)urea

Systematic Name

English

Code System Code Type Description

INN

12863