FLOSULIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13F2NO4S
Molecular Weight	353.341
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(=O)(=O)NC1=CC2=C(C=C1OC3=C(F)C=C(F)C=C3)C(=O)CC2

InChI

InChIKey=CXJONBHNIJFARE-UHFFFAOYSA-N

InChI=1S/C16H13F2NO4S/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11321358 | https://www.ncbi.nlm.nih.gov/pubmed/9892207 | https://www.ncbi.nlm.nih.gov/pubmed/10571785

Flosulide, a selective cyclooxygenase-2 (COX-2) inhibitor, was studied for the treatment for inflammatory diseases. It was shown, that selective inhibition of COX-2 could alter renal function and could be useful in the therapy of esophageal cancer. Experiments on rodent have revealed that therapeutic use of flosulide in proteinuria could be a benefit.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: https://adisinsight.springer.com/drugs/800000942\|https://www.ncbi.nlm.nih.gov/pubmed/8523403\|https://www.ncbi.nlm.nih.gov/pubmed/9892207	Inhibitor 8297		21.0 nM [IC50]

PubMed

Title	Date	PubMed
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.	1997 May	9146894
Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.	2004 Feb 1	14510637

Patents

Name

Type

Language

FLOSULIDE

Official Name

English

flosulide [INN]

Common Name

English

N-(6-(2,4-DIFLUOROPHENOXY)-1-OXO-5-INDANYL)METHANESULFONAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1323