Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H8N2 |
| Molecular Weight | 144.1732 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=C2C=CC=CC2=NC=C1
InChI
InChIKey=FQYRLEXKXQRZDH-UHFFFAOYSA-N
InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment. | 2010-02 |
|
| Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. | 2009-12-01 |
|
| Genetic basis of inherited macular dystrophies and implications for stem cell therapy. | 2009-11 |
|
| Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain. | 2009-09-15 |
|
| Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity. | 2009-09-01 |
|
| 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. | 2009-07-24 |
|
| Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. | 2009-07-14 |
|
| A comparative, randomized clinical trial of artemisinin/naphtoquine twice daily one day versus artemether/lumefantrine six doses regimen in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire. | 2009-07-03 |
|
| Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model. | 2009-07 |
|
| In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. | 2009-06-01 |
|
| Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials. | 2009-05-01 |
|
| Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity. | 2009-04 |
|
| Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination. | 2009-03-30 |
|
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | 2009-03-12 |
|
| Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. | 2009-01-22 |
|
| Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. | 2009-01 |
|
| Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents. | 2008-12-15 |
|
| Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. | 2008-12-07 |
|
| Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action. | 2008-11-20 |
|
| New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton. | 2008-10-09 |
|
| Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice. | 2008-10 |
|
| Synthesis and antimalarial activity of novel side chain modified antimalarial agents derived from 4-aminoquinoline. | 2008-09 |
|
| Synthesis and antimalarial activity of new amino analogues of amodiaquine. | 2008-09 |
|
| Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase. | 2008-08-15 |
|
| Molecular epidemiology of drug-resistant malaria in western Kenya highlands. | 2008-07-31 |
|
| Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline. | 2008-07-01 |
|
| Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A. | 2008-07-01 |
|
| Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population. | 2008-05-06 |
|
| The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea. | 2008-04-19 |
|
| Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. | 2008-03-13 |
|
| Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. | 2008-02-13 |
|
| Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. | 2008-02 |
|
| [Urotensin II promotes atherosclerosis]. | 2008-01 |
|
| Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro. | 2008 |
|
| Bis-quinolinium cyclophanes: highly potent and selective non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. | 2008 |
|
| Metallocene antimalarials: the continuing quest. | 2008 |
|
| Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry. | 2007-12-01 |
|
| Chloroquine ototoxicity. | 2007-11 |
|
| In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border. | 2007-06-27 |
|
| Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. | 2007-06-15 |
|
| Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses. | 2007-05-03 |
|
| Response to malaria epidemics in Africa. | 2007-05 |
|
| Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance. | 2007-05 |
|
| Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular field analysis studies. | 2007-04-12 |
|
| Synthesis and antimalarial activity of new isotebuquine analogues. | 2007-02-22 |
|
| Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed? | 2007-02-16 |
|
| Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. | 2007-01-25 |
|
| Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides. | 2007-01-01 |
|
| [Ocular toxicity due to 4-aminoquinoline derivatives]. | 2006-11-08 |
|
| The use of antirheumatic disease drugs during pregnancy. | 2006-11 |
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GTE5P5L97N
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C001920
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578-68-7
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68476
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DTXSID70206491
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4-AMINOQUINOLINE
Created by
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SUBSTANCE RECORD
