NICOBOXIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H17NO3
Molecular Weight	223.2683
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCOCCOC(=O)C1=CC=CN=C1

InChI

InChIKey=IZJRISIINLJVBU-UHFFFAOYSA-N

InChI=1S/C12H17NO3/c1-2-3-7-15-8-9-16-12(14)11-5-4-6-13-10-11/h4-6,10H,2-3,7-9H2,1H3

HIDE SMILES / InChI

Description
Sources: https://gp2u.com.au/static/pdf/F/FINALGON-PI.pdf
Curator's Comment: for description additional reference was used http://onlinelibrary.wiley.com/doi/10.1002/ejp.719/full

Nicoboxil is a nicotinate used in topical preparations as a rubefacient which has vasodilating properties mediated by prostaglandin. Nicoboxil is a component of finalgon® (nonivamid and nicoboxil), a topical cream for joint and muscle pains. The hyperaemic effect of Nicoboxil has an earlier onset and it is more intense than the nonivamide hyperaemic effect.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
positive regulation of vasodilation 1 Target ID: GO:0045909 Sources: http://onlinelibrary.wiley.com/doi/10.1002/ejp.719/full	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: https://gp2u.com.au/static/pdf/F/FINALGON-PI.pdf	Primary		Approved 8583	Finalgon Approved Use Nicobaxol as a component of Finalgon is used for the temporary relief of the pain of rheumatism, arthritis, lumbago, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Launch Date 1994

PubMed

Title	Date	PubMed
Topical application of cream containing nonivamide and nicoboxil does not enhance the performance of experienced cyclists during a 4-km time-trial.	2016-05	27002820
Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back - A randomized, controlled trial.	2016-02	25929250
Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream.	2014-02	24502638
A comparison of pretreatment with a topical combination of nonivamide and nicoboxil and surgical delay in a random pattern skin flap model.	2009-07	18456588
Improved dorsal random-pattern skin flap survival in rats with a topically applied combination of nonivamide and nicoboxil.	2003-03	12621192

Sample Use Guides

In Vivo Use Guide

Ointment; Topical; Nonivamide 0.4% mg; Nicoboxil 2.5%

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

BUTOXYETHYL NICOTINATE

Preferred Name

English

NICOBOXIL

Official Name

English

NICOBOXIL [MART.]

Common Name

English

nicoboxil [INN]

Common Name

English

BETA-BUTOXYETHYL NICOTINATE [JAN]

Common Name

English

BETA-BUTOXYETHYL NICOTINATE

Systematic Name

English

2-BUTOXYETHYL NICOTINATE

Systematic Name

English

Nicoboxil [WHO-DD]

Common Name

English

.BETA.-BUTOXYETHYL NICOTINATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241