Stereochemistry | ACHIRAL |
Molecular Formula | C20H30N4O2 |
Molecular Weight | 358.4778 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC1=NC2=CC(\C=C\C(=O)NO)=CC=C2N1CCN(CC)CC
InChI
InChIKey=JHDKZFFAIZKUCU-ZRDIBKRKSA-N
InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
Originator
Approval Year
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
The recommended dose is 60 mg given by mouth every other day, three times weekly for 3 weeks
Route of Administration:
Oral
Three micrograms of protein lysate from either HCT116 or HL-60 cells were treated for 24 hours with 2 uM pracinostat to obtain a strong acetylation of K9 and K14 of histone H3. The lowest concentration of the drug leading to acH3 was 22 ng/mL (0.06 uM) for both HCT-116 and HL-60 cells treated for 24 hours with pracinostat. In HL-60 cells, maximal acH3 levels were reached at 1 uM not increasing further after treatment with 2 uM.