Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C19H23F2N3O3 |
| Molecular Weight | 379.401 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCNCC1CCN(C1)C2=C(F)C3=C(C=C2F)C(=O)C(=CN3CC)C(O)=O
InChI
InChIKey=BAYYCLWCHFVRLV-UHFFFAOYSA-N
InChI=1S/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27)
Merafloxacin (CI 934) is a quinolone antibacterial. It is an inhibitor of Type II DNA topoisomerase. It demonstrated excellent activity against gram-positive organisms, including Corynebacterium sp. In addition, although the activity of merafloxacin against gram-negative bacilli was less than that reported for similar agents, it was comparable to that of aminoglycosidic aminocyclitol antibiotics. Merafloxacin development has been discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Determination of MICs of conventional and experimental drugs in liquid medium by the radiometric method against Mycobacterium avium complex. | 1987 |
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| Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria. | 1987 Apr 27 |
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| In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis. | 1987 May |
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| Comparative in-vitro activities of ten fluoroquinolones and fusidic acid against Mycobacterium spp. | 1990 Sep |
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| In-vitro activities of quinolones against mycobacteria. | 1993 Dec |
|
| Anti-Mycobacterium avium activity of quinolones: in vitro activities. | 1993 Sep |
|
| Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening. | 2000 Oct |
Patents
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C795
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EE-38
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G6U51T1K77
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CHEMBL6209
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C83932
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ACTIVE MOIETY
