Stereochemistry | ABSOLUTE |
Molecular Formula | C11H10N2O2 |
Molecular Weight | 202.2093 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2=O
InChI
InChIKey=SDIVYZXRQHWCKF-VIFPVBQESA-N
InChI=1S/C11H10N2O2/c14-9-5-6-13-10(9)12-8-4-2-1-3-7(8)11(13)15/h1-4,9,14H,5-6H2/t9-/m0/s1
Vasicinone is a quinazoline alkaloid. Hepatoprotective activity of vasicinone has being shown in mice. Pre-treatment with vasicinone and silymarin (25 mg/kg/day for 7 days) significantly decreased CCl4-induced increase in SGOT, SGPT, ALP levels. Vasicinone has shown cytotoxic and antiproliferative activity in several tumor cell lines. Vasicinone, an oxidation product of vascinine is a potent bronchodialator. Vasicinone could be utilised in alternate anti asthmatic therapy, since it plays a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.
Approval Year
PubMed
Patents
Sample Use Guides
Rats experimental arthritis model: maximum inhibition rate was observed of vasicinone (63.94%) atter dose of 10.0 mg/kg p.o at 4 days after CFA injection.
Route of Administration:
Oral