Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H20ClN3O3S |
| Molecular Weight | 369.866 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CN(C[C@]1([H])[C@@H]3CC[C@H]2C3)NC(=O)C4=CC=C(Cl)C(=C4)S(N)(=O)=O
InChI
InChIKey=UHLOVGKIEARANS-NIFPGPBJSA-N
InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12-,13+
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/6861441 and http://www.genome.jp/dbget-bin/www_bget?D01895
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/6861441 and http://www.genome.jp/dbget-bin/www_bget?D01895
Tripamide is a new diuretic derived from a sulfonamide nucleus that has both antihypertensive and natriuretic properties. It is Na-K-Cl cotransporter inhibitor. The antihypertensive mechanism of tripamide is considered to be based on a mild saluretic action and a peripheral vasodilation action. Tripamide is an ingredient of Normonal in Japan, indicated for the treatment of essential hypertension.
Approval Year
Sample Use Guides
The usual adult dosage for oral use is 15 mg of tripamide (one
tablet) once to twice daily after breakfast or after breakfast and
lunch
Route of Administration:
Oral
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NCI_THESAURUS |
C448
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m11179
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TRIPAMIDE
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C152751
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DTXSID2057817
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ACTIVE MOIETY
