Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H17N2O3.Na |
| Molecular Weight | 248.254 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCC1(CCC(C)C)C(=O)NC(=O)[N-]C1=O
InChI
InChIKey=BNHGKKNINBGEQL-UHFFFAOYSA-M
InChI=1S/C11H18N2O3.Na/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1
AMOBARBITAL is a barbiturate derivative with hypnotic and sedative properties. In an in vitro study in rat thalamic slices amobarbital worked by activating GABAA receptors, which decreased input resistance, depressed burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increased both the amplitude and decay time of inhibitory postsynaptic currents. Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The alcoholic metabolites of pentobarbital and amobarbital in man. | 1965 Oct |
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| Dystonic reactions to prochlorperazine in hypoparathyroidism. | 1966 Nov 3 |
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| Hypotensive effects of chlordiazepoxide, amobarbital and chlorpromazine on behaviorally induced elevated arterial blood pressure in the squirrel monkey. | 1970 Jun |
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| The addition of intravenous caffeine during an amobarbital interview. | 1992 Nov |
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| Clinical experimental observations of carotid artery injections of sodium amytal. | 1997 Feb |
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| Hippocampal sclerosis: correlation of MR imaging findings with surgical outcome. | 2001 Apr-Jun |
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| Neuroprotective role of neurophysiological monitoring during endovascular procedures in the spinal cord. | 2001 Jun |
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| On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria. | 2003 Mar 15 |
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| Neurophysiologic monitoring and pharmacologic provocative testing for embolization of spinal cord arteriovenous malformations. | 2004 Aug |
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| Selective GABA-receptor actions of amobarbital on thalamic neurons. | 2004 Oct |
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| Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy in high myopia: a prospective clinical study. | 2004 Sep 14 |
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| Amygdalohippocampal involvement in tinnitus and auditory memory. | 2006 Dec |
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| Seizures during intracarotid methohexital and amobarbital testing. | 2007 Feb |
|
| In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 Jan |
|
| Preoperative cellulose porous beads for therapeutic embolization of meningioma: provocation test and technical considerations. | 2007 May |
|
| Perioperative modulating factors on astigmatism in sutured cataract surgery. | 2009 Dec |
|
| Acquired and congenital disorders of sung performance: A review. | 2009 Nov 12 |
|
| Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology. | 2010 Mar 3 |
|
| Prozone effect of serum IgE levels in a case of plasma cell leukemia. | 2010 Sep 10 |
Patents
Sample Use Guides
Sedative: 30 to 50 mg given 2 or 3 times daily.
Hypnotic: 65 to 200 mg at bedtime.
Route of Administration:
Oral
To 100mkl of the tissue homogenate were added 50 mkl of [3SS]TBPS (at the appropriate concentration, and made in 1 M NaBr), 50 mkl of 50 mM Tris Citrate buffer (to define total binding) or AMOBARBITAL at 100mkM or 50mkl of 40mkM picrotoxinin (to define nonspecific binding). The mixture was incubated 90 min at 21°C and then filtered over glass-fiber filters (Schleicher and Schuell No. 32). Filters were washed three times with 5 ml 0.9% (w:v) NaC1 equilibrated to 21°C and then counted by liquid scintillation spectrometry.
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| Classification Tree | Code System | Code | ||
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DEA NO. |
2125
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NCI_THESAURUS |
C67084
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1314242
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G0313KNC7D
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64-43-7
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C76524
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DTXSID40213975
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m1837
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100000085178
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CHEMBL267894
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SUB00498MIG
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13389383
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DBSALT001490
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ACTIVE MOIETY
SUBSTANCE RECORD
