Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C10H12ClNO4 |
| Molecular Weight | 245.66 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)OCC(O)COC1=CC=C(Cl)C=C1
InChI
InChIKey=SKPLBLUECSEIFO-UHFFFAOYSA-N
InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)
DescriptionSources: doi:10.1001/jama.1966.03100220075024Curator's Comment: description was created based on several sources, including:
http://www.drugs.com/mtm/chlorphenesin.html
http://www.drugbank.ca/drugs/DB00856
https://en.wikipedia.org/wiki/Chlorphenesin
Sources: doi:10.1001/jama.1966.03100220075024
Curator's Comment: description was created based on several sources, including:
http://www.drugs.com/mtm/chlorphenesin.html
http://www.drugbank.ca/drugs/DB00856
https://en.wikipedia.org/wiki/Chlorphenesin
Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. Сhlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle. It also has antifungal and some antibacterial properties. The major adverse effects are drowsiness and dizziness.
CNS Activity
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
14.9 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/5133920/ |
2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered: METHOCARBAMOL |
CHLORPHENESIN CARBAMATE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
84 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/5133920/ |
2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered: METHOCARBAMOL |
CHLORPHENESIN CARBAMATE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.44 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/5133920/ |
2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered: METHOCARBAMOL |
CHLORPHENESIN CARBAMATE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011-07-14 |
|
| Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial. | 2009-11 |
|
| Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells. | 2003-01-03 |
Patents
Sample Use Guides
for adults is 1.6 to 2.4 gm given in divided doses
Route of Administration:
Oral
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Common Name | English | ||
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Preferred Name | English |
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G014XC07GH
Created by
admin on Mon Mar 31 23:28:25 GMT 2025 , Edited by admin on Mon Mar 31 23:28:25 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
