Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H13NO4 |
Molecular Weight | 163.1717 |
Optical Activity | ( + ) |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
Duvoglustat, an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and Commelina communis (dayflower) as well as from several bacterial strains such as Bacillus and Streptomyces species. Duvoglustat is an investigational pharmacological chaperone for the treatment of acid α-glucosidase (GAA) deficiency, which leads to the lysosomal storage disorder Pompe disease, which is characterized by progressive accumulation of lysosomal glycogen primarily in heart and skeletal muscles. Duvoglustat possesses antihyperglycemic, anti-obesity, and antiviral features. Most importantly, pre-meal intake of duvoglustat in therapeutic concentration has resulted in the inhibition of postprandial hyperglycemia and hyperinsulinemia. Thus, duvoglustat seems to be a potential treatment for checking or setting back the inception of diabetes. No duvoglustat-related adverse events or drug-related tolerability issues were identified in phase II clinical trial for the treatment of Pompe disease.
Approval Year
PubMed
Title | Date | PubMed |
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6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs. | 1991 Jun |
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Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. | 2002 Sep |
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Imino sugars are potent agonists of the human glucose sensor SGLT3. | 2007 Feb |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28341561
Single doses - 50 mg, 100 mg, 250 mg, or 600 mg
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C87006
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DSLD |
1116 (Number of products:2)
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m4176
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44369
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29435
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9192
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CHEMBL307429
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1-Deoxynojirimycin
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300000034137
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DTXSID70172647
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UU-168
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FZ56898FLE
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19130-96-2
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DB03206
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C87373
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)