TOSACTIDE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5108727 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 206, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Tosactide is a synthetic peptide, a structural corticotropin analog (the first 28 amino acids of human adrenocorticotropin). The time course shows that the duration of action is short with a maximum effect at about 30 minutes and returns to a resting value soon after three hours. Tosactide has been used clinically.

Approval Year

PubMed

Title	Date	PubMed
Adrenocortical function of patients using oral contraceptives.	1974	4362662
A rapid test of adrenocortical function using HOMACTID (synthetic alpha-h 1-28 ACTH).	1971-07	5108727
[Comparative study of the adrenocorticotrophic action of the synthetic polypeptides Humacthid-28 and Synacthen in man].	1971-03	4325433

Sample Use Guides

In Vivo Use Guide

Single injection - 10 ug

Route of Administration: Intravenous

Name

Type

Language

TOSACTIDE

Official Name

English

.ALPHA.1-28-CORTICOTROPIN

Preferred Name

English

.ALPHA.1-28-CORTICOTROPIN (SWINE), 25-L-ASPARTIC ACID-26-L-ALANINE-27-GLYCINE-

Common Name

English

SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASP-ALA-GLY-GLU

Common Name

English

tosactide [INN]

Common Name

English

.ALPHA.1-28-CORTICOTROPIN (PIG), 25-L-ASPARTIC ACID-26-L-ALANINE-27-GLYCINE-

Common Name

English

OCTACOSACTRIN

Common Name

English

.ALPHA.1-28-CORTICOTROPIN (HUMAN)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C212