Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27ClO5 |
| Molecular Weight | 406.9 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)OC[C@]4(C)[C@H]3CC[C@]12C)C(C)=O
InChI
InChIKey=KKTIOMQDFOYCEN-OFUYBIASSA-N
InChI=1S/C22H27ClO5/c1-12(24)22(28-13(2)25)8-6-16-14-9-18(23)17-10-19(26)27-11-20(17,3)15(14)5-7-21(16,22)4/h9-10,14-16H,5-8,11H2,1-4H3/t14-,15+,16+,20-,21+,22+/m1/s1
Osaterone acetate (previously known as TZP-4238), a synthetic steroidal anti-androgen agent. Osaterone acetate is used in veterinary in Europe in the treatment of benign prostatic hyperplasia (BPH) in male dogs. Osaterone acetate inhibits the effects of an excess of male hormone (testosterone) through various mechanisms. It competitively prevents the binding of androgens to their prostatic receptors and blocks the transport of testosterone into the prostate. Osaterone acetate was also investigated in Japan in the treatment of prostate cancer and BPH and, in addition, was studied in postmenopausal osteoporosis in humans. However, these studies were discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs. | 2002-02 |
|
| [Effects of antiandrogen TZP-4238 on the prostatic androgen receptor and prostatic androgen in rat]. | 1994-10-20 |
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| [The effect of TZP-4238, an anti-androgen drug, on renal function]. | 1994-08 |
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| Inhibitory influence of a new steroidal anti-androgen, TZP-4238, on prostatic hyperplasia in the beagle dog. | 1992-03 |
|
| Effect of anti-androgen (TZP-4238) on steroid-induced canine prostatic hyperplasia. Light and electron microscopic investigations. | 1990-12 |
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EMA VETERINARY ASSESSMENT REPORTS |
YPOZANE [AUTHORIZED]
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Osaterone acetate
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METABOLITE ACTIVE (PARENT)
SUBSTANCE RECORD
