SODIUM LACTATE, D-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C3H5O3.Na
Molecular Weight	112.0598
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].C[C@@H](O)C([O-])=O

InChI

InChIKey=NGSFWBMYFKHRBD-HSHFZTNMSA-M

InChI=1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m1./s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4435109 | https://www.ncbi.nlm.nih.gov/pubmed/25542530 | https://www.ncbi.nlm.nih.gov/pubmed/27654657

Lactic acid, D- is a natural optical isomer of lactic acid. It is a poorly utilized isomer – 30 to 40% of the dose ingested is excreted in the urine. Lactic acid, D- is known to be harmful to human metabolism and it can result in acidosis and decalcification. D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome. Lactic acid, D- is an interesting precursor for manufacturing heat-resistant polylactic acid (PLA) bioplastics which can be widely used, for example as packaging material, coatings, for textiles or in the automotive industry.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Fluorimetric assay of D-lactate.	1992 Oct	1456422
[Content of free amino acids in blood plasma of the clean-up personnel at the Chernobyl nuclear power plant accident].	2002 Sep-Oct	12916164
Total calcium content of sacs associated with inguinal hernia, hydrocele or undescended testis reflects differences dictated by programmed cell death.	2003	12660459
Thermal inactivation of Escherichia coli O157:H7 in ground beef supplemented with sodium lactate.	2003 Apr	12696693
Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products.	2003 Apr	12660223
Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent.	2003 Apr	12631356
Inhibition of nonproteolytic, psychrotrophic clostridia and anaerobic sporeformers by sodium diacetate and sodium lactate in cook-in-bag turkey breast.	2003 Aug	12929840
Use of organic acids for the control of Clostridium perfringens in cooked vacuum-packaged restructured roast beef during an alternative cooling procedure.	2003 Aug	12929827
Flicker light-induced vasodilatation in the human retina: effect of lactate and changes in mean arterial pressure.	2003 Dec	14638731
Lactate depresses sarcolemmal permeability of Ca2+ in intact arterial smooth muscle.	2003 Dec 19	14623035
Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.	2003 Feb	12701804
Selective enumeration of Lactobacillus delbrueckii ssp. bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, bifidobacteria, Lactobacillus casei, Lactobacillus rhamnosus, and propionibacteria.	2003 Jul	12906045
Correlates of therapeutic response in panic disorder presenting with palpitations: heart rate variability, sleep, and placebo effect.	2003 Jul	12894612
pH and energy dependent transport of ketoprofen across rat jejunum in vitro.	2003 Jul	12837486
Lactate: a preferred fuel for human brain metabolism in vivo.	2003 Jun	12796713
Acid diffusion through extracellular polysaccharides produced by various mutants of Streptococcus mutans.	2003 Jun	12749915
Effects of acid adaptation and modified marinades on survival of postdrying Salmonella contamination on beef jerky during storage.	2003 Mar	12636291
High production system of the antibacterial peptide PLG-1.	2003 Mar-Apr	12675584
[Na+ overload-induced mitochondrial dysfunction in myocardial ischemia/reperfusion injury].	2003 May	12784736
Growth and germination of proteolytic Clostridium botulinum in vegetable-based media.	2003 May	12747693
Predictive model for the combined effect of temperature, sodium lactate, and sodium diacetate on the heat resistance of Listeria monocytogenes in beef.	2003 May	12747689
Intravenous fluid loading with or without supplementary dextrose does not prevent nausea, vomiting and pain after laparoscopy.	2003 May	12734150
Erosion of water-based cements evaluated by volumetric and gravimetric methods.	2003 May	12628437
Coping strategies of panic and control subjects undergoing lactate infusion during magnetic resonance imaging confinement.	2003 May-Jun	12764706
Radiation (gamma) resistance and postirradiation growth of Listeria monocytogenes suspended in beef bologna containing sodium diacetate and potassium lactate.	2003 Nov	14627282
Determination of serum D-lactic and L-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization.	2003 Nov	12879188
[Application of sorbilact for treatment of postoperative paralytic ileus in cancer of the esophagus and stomach].	2003 Sep	14663900
[Experimental provocation of panic attacks as a human experimental model for anxiety].	2003 Sep	14504770
Effect of intravenous administration of sodium-lactate on retinal blood flow in healthy subjects.	2003 Sep	12939317
Influence of marinades on survival during storage of acid-adapted and nonadapted Listeria monocytogenes inoculated post-drying on beef jerky.	2003 Sep 15	12915039
Thermal resistances and lactate and diacetate sensitivities of bacteria causing bologna discolouration.	2003 Sep 15	12915033
Antimicrobial activity of enterocin EJ97 against 'Bacillus macroides/Bacillus maroccanus' isolated from zucchini purée.	2004	15357722
Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders.	2004 Apr 7	15071094
Factors that contribute to the botulinal safety of reduced-fat and fat-free process chesse products.	2004 Aug	15330535
Advanced in vitro production of pig blastocysts obtained through determining the time for glucose supplementation.	2004 Feb	15007204
Preservation of mitochondrial function during ischemia as a possible mechanism for cardioprotection of diltiazem against ischemia/reperfusion injury.	2004 Feb 1	15037208
A select group of perpetrators of domestic violence: evidence of decreased metabolism in the right hypothalamus and reduced relationships between cortical/subcortical brain structures in position emission tomography.	2004 Jan 15	14972365
Evaluation of a challenge testing protocol to assess the stability of ready-to-eat cooked meat products against growth of Listeria monocytogenes.	2004 Jan 15	14698103
Evaluation of Staphylococcus aureus growth potential in ham during a slow-cooking process: use of predictions derived from the U.S. Department of Agriculture Pathogen Modeling Program 6.1 predictive model and an inoculation study.	2004 Jul	15270512
Effect of sodium lactate on thermal inactivation of Listeria monocytogenes and Salmonella in ground chicken thigh and leg meat.	2004 Jul	15270493
Effects of ingestion of bicarbonate, citrate, lactate, and chloride on sprint running.	2004 Jul	15235332
Inhibitory effects of organic acid salts on growth of Clostridium perfringens from spore inocula during chilling of marinated ground turkey breast.	2004 Jun 1	15135954
Electrolyte mass balance during CVVH: lactate vs. bicarbonate-buffered replacement fluids.	2004 Mar	15287198
Sodium lactate addition on the quality and shelf life of refrigerated sliced poultry sausage packaged in air or nitrogen atmosphere.	2004 Mar	15035381
Development of a novel approach for secondary modelling in predictive microbiology: incorporation of microbiological knowledge in black box polynomial modelling.	2004 Mar 15	14984771
Selenate reduction in river water by Citerobacter freundii isolated from a selenium-contaminated sediment.	2004 Mar 24	15030217
Acidosis counteracts the negative inotropic effect of K+ on ventricular muscle strips from the toad Bufo marinus.	2004 Mar-Apr	15095242
An enzymatic route to produce pyruvate from lactate.	2004 Nov	15252696
Modelling the electrodialytic recovery of sodium lactate.	2004 Oct	15003107
Effect of intraoperative intravenous crystalloid infusion on postoperative nausea and vomiting after gynaecological laparoscopy: comparison of 30 and 10 ml kg(-1).	2004 Sep	15220164

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The effects of a 24-h exposure to 20 mM of D-lactic acid on ceramide levels of keratinocytes were investigated. D-Lactic acid increased ceramide levels but the increase was not statistically significant (100% increase).

Name

Type

Language

SODIUM LACTATE, D-

Common Name

English

SODIUM D-LACTATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29730