U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C25H23F3N2O4S
Molecular Weight 504.521
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FONADELPAR

SMILES

CC(C)C1=C(CCC2=NOC3=CC(OCC(O)=O)=C(C)C=C23)SC(=N1)C4=CC=C(C=C4)C(F)(F)F

InChI

InChIKey=WWKYLBGQYALEDL-UHFFFAOYSA-N
InChI=1S/C25H23F3N2O4S/c1-13(2)23-21(35-24(29-23)15-4-6-16(7-5-15)25(26,27)28)9-8-18-17-10-14(3)19(33-12-22(31)32)11-20(17)34-30-18/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,31,32)

HIDE SMILES / InChI
Senju Pharmaceutical is developing fonadelpar (also known as SJP-0035), a peroxisome proliferator activated receptor delta agonist as an ophthalmic solution. Fonadelpar was studied in phase III clinical trial in the USA for the treatment of patients with dry eye disease. This study was successfully completed. In addition, fonadelpar was involved in phase II clinical trial in the USA for the treatment of patients with moderate to severe corneal epithelial disorders. Besides, Senju Pharmaceutical also plans a phase II trial for corneal disorders in Japan.

Approval Year

Sample Use Guides

Self-administration of 1 drop (approximately 40 µL) of 0.001% SJP-0035 (FONADELPAR) ophthalmic solution into each eye 4 times daily for 4 weeks
Route of Administration: Other
Name Type Language
FONADELPAR
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
Fonadelpar [WHO-DD]
Common Name English
SJP-0035
Code English
(3-(2-(4-ISOPROPYL-2-(4-(TRIFLUOROMETHYL)PHENYL)-5-THIAZOLYL)ETHYL-5-METHYL-1,2-BENZISOXAZOL-6-YL)OXYACETIC ACID
Systematic Name English
NPS-005
Code English
FONADELPAR [USAN]
Common Name English
ACETIC ACID, 2-((5-METHYL-3-(2-(4-(1-METHYLETHYL)-2-(4-(TRIFLUOROMETHYL)PHENYL)-5-THIAZOLYL)ETHYL)-1,2-BENZISOXAZOL-6-YL)OXY)-
Systematic Name English
fonadelpar [INN]
Common Name English
Code System Code Type Description
USAN
BC-86
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
PRIMARY
NCI_THESAURUS
C170003
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
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ChEMBL
CHEMBL3545186
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
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FDA UNII
FK5ZAD810Z
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
PRIMARY
CAS
515138-06-4
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
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PUBCHEM
9827461
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
PRIMARY
SMS_ID
300000034227
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
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INN
10105
Created by admin on Sat Dec 16 08:31:52 GMT 2023 , Edited by admin on Sat Dec 16 08:31:52 GMT 2023
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